C57BL/6N-Atm1Brd Rpgrip1ltm1a(EUCOMM)Wtsi/WtsiBiat

Status

Available to order

EMMA IDEM:05968
International strain nameC57BL/6N-Atm1Brd Rpgrip1ltm1a(EUCOMM)Wtsi/WtsiBiat
Alternative nameEPD0373_5_A04
Strain typeTargeted Mutant Strains
Allele/Transgene symbolRpgrip1ltm1a(EUCOMM)Wtsi,
Gene/Transgene symbolRpgrip1l
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0373_5_A04. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • preweaning lethality, complete penetrance / IMPC
MGI phenotypes (allele matching)
  • abnormal inner ear morphology / MGI
  • abnormal basioccipital bone morphology / MGI
  • abnormal basisphenoid bone morphology / MGI
  • cleft palate / MGI
  • abnormal vertebral body morphology / MGI
  • abnormal rib morphology / MGI
  • double outlet right ventricle / MGI
  • abnormal atrioventricular cushion morphology / MGI
  • abnormal maxilla morphology / MGI
  • polydactyly / MGI
  • enlarged liver sinusoidal spaces / MGI
  • abnormal pineal gland morphology / MGI
  • absent spleen / MGI
  • spleen hypoplasia / MGI
  • abnormal forebrain morphology / MGI
  • abnormal olfactory bulb morphology / MGI
  • abnormal hindbrain morphology / MGI
  • abnormal midbrain morphology / MGI
  • small dorsal root ganglion / MGI
  • absent superior cervical ganglion / MGI
  • small superior cervical ganglion / MGI
  • absent oculomotor nerve / MGI
  • abnormal accessory nerve morphology / MGI
  • abnormal testis morphology / MGI
  • anophthalmia / MGI
  • abnormal nasal cavity morphology / MGI
  • abnormal nasal septum morphology / MGI
  • abnormal hyoid bone morphology / MGI
  • left pulmonary isomerism / MGI
  • liver cysts / MGI
  • absent olfactory bulb / MGI
  • bifid ureter / MGI
  • abnormal eye muscle morphology / MGI
  • abnormal palate morphology / MGI
  • liver hemorrhage / MGI
  • transposition of great arteries / MGI
  • heterotaxia / MGI
  • right aortic arch / MGI
  • abnormal carotid artery morphology / MGI
  • abnormal optic stalk morphology / MGI
  • abnormal optic cup morphology / MGI
  • abnormal vertebral arch morphology / MGI
  • fusion of vertebral arches / MGI
  • absent vertebral body / MGI
  • abnormal brain vasculature morphology / MGI
  • holoprosencephaly / MGI
  • cleft upper lip / MGI
  • abnormal incisor morphology / MGI
  • abnormal heart position or orientation / MGI
  • absent brain internal capsule / MGI
  • absent adenohypophysis / MGI
  • left atrial isomerism / MGI
  • thoracoschisis / MGI
  • absent sublingual gland / MGI
  • abnormal right lung morphology / MGI
  • absent optic chiasm / MGI
  • decreased tongue size / MGI
  • atrial septal defect / MGI
  • common atrium / MGI
  • perimembraneous ventricular septal defect / MGI
  • muscular ventricular septal defect / MGI
  • double outlet left ventricle / MGI
  • atrial situs inversus / MGI
  • anomalous pulmonary venous connection / MGI
  • abnormal inferior vena cava valve morphology / MGI
  • persistent right dorsal aorta / MGI
  • abdominal situs ambiguus / MGI
  • abnormal internal carotid artery morphology / MGI
  • abnormal basilar artery morphology / MGI
  • thin facial nerve / MGI
  • abnormal intrathoracic topology of vagus nerve / MGI
  • thin hypoglossal nerve / MGI
  • absent hypoglossal nerve / MGI
  • abnormal hypoglossal nerve topology / MGI
  • absent segment of posterior cerebral artery / MGI
  • subcutaneous edema / MGI
  • abnormal Mullerian duct topology / MGI
  • abnormal hepatic portal vein formation / MGI
  • abnormal azygos vein topology / MGI
  • abnormal vitelline vein connection / MGI
  • abnormal pancreas topology / MGI
  • abnormal ventral pancreas morphology / MGI
  • absent ductus venosus valve / MGI
  • abnormal ductus venosus valve topology / MGI
  • absent intracranial segment of vertebral artery / MGI
  • persistent right 6th pharyngeal arch artery / MGI
  • thin motoric part of trigeminal nerve / MGI
  • retro-esophageal left subclavian artery / MGI
  • absent connection between subcutaneous lymph vessels and lymph sac / MGI
  • abnormal coronary sinus connection / MGI
  • symmetric azygos veins / MGI
  • abnormal subclavian artery origin / MGI
  • inverse situs of great intrathoracic arteries / MGI
  • abnormal umbilical vein topology / MGI
  • absent intrahepatic inferior vena cava segment / MGI
  • abnormal vertebral artery origin / MGI
  • abnormal internal carotid artery topology / MGI
  • absent canalicular internal carotid artery segment / MGI
  • absent parasellar internal carotid artery / MGI
  • anastomosis between internal carotid artery and basilar artery / MGI
  • abnormal cranial blood vasculature morphology / MGI
  • heterochrony / MGI
  • abnormal intestine placement / MGI

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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