B6;129P2-Nkx6-2tm2(cre)Ercs/Kctt
Status | Available to order |
EMMA ID | EM:06022 |
International strain name | B6;129P2-Nkx6-2tm2(cre)Ercs/Kctt |
Alternative name | Nkx6.2tm2Ercs / Nkx6.2Cre |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Nkx6-2tm2(cre)Ercs, |
Gene/Transgene symbol | Nkx6-2 |
Information from provider
Provider | Elisabet Andersson |
Provider affiliation | Dept. Comparative Medicine, KCTT, Karolinska Institutet |
Genetic information | The entire coding region was replaced with a cassette containing Cre and neomycin. Cre is expressed from this allele under the control of the endogenous promoter. |
Phenotypic information | Mice homozygous for the mutant alleles were born at Mendelian frequency and survived through adulthood. No abnormal phenotype was observed. Similar to Nkx6.2tm1(lacZ)Ercs: nervous system abnormal axon outgrowth: axonal tracts are thinner than in wild-type mice, especially for the tenth cranial nerve; abnormal vagus ganglion morphology: axonal tracts are thinner than in wild-type mice, especially for the tenth cranial nerve. Cellular abnormal axon outgrowth: axonal tracts are thinner than in wild-type mice, especially for the tenth cranial nerve. |
Breeding history | Mixed, not congenic. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Karolinska Institutet, Stockholm, Sweden |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- NKX6-2-related autosomal recessive hypomyelinating leukodystrophy / Orphanet_527497
Literature references
- Retrograde signaling onto Ret during motor nerve terminal maturation.;Baudet Christel, Pozas Ester, Adameyko Igor, Andersson Elisabet, Ericson Johan, Ernfors Patrik, ;2008;The Journal of neuroscience : the official journal of the Society for Neuroscience;28;963-75; 18216204
- Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain.;Pattyn Alexandre, Vallstedt Anna, Dias Jose M, Sander Maike, Ericson Johan, ;2003;Development (Cambridge, England);130;4149-59; 12874134
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