B6;129P2-Nkx6-2tm2(cre)Ercs/Kctt

Status

Available to order

EMMA IDEM:06022
International strain nameB6;129P2-Nkx6-2tm2(cre)Ercs/Kctt
Alternative nameNkx6.2tm2Ercs / Nkx6.2Cre
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolNkx6-2tm2(cre)Ercs,
Gene/Transgene symbolNkx6-2

Information from provider

ProviderElisabet Andersson
Provider affiliationDept. Comparative Medicine, KCTT, Karolinska Institutet
Genetic informationThe entire coding region was replaced with a cassette containing Cre and neomycin. Cre is expressed from this allele under the control of the endogenous promoter.
Phenotypic informationMice homozygous for the mutant alleles were born at Mendelian frequency and survived through adulthood. No abnormal phenotype was observed. Similar to Nkx6.2tm1(lacZ)Ercs: nervous system abnormal axon outgrowth: axonal tracts are thinner than in wild-type mice, especially for the tenth cranial nerve; abnormal vagus ganglion morphology: axonal tracts are thinner than in wild-type mice, especially for the tenth cranial nerve. Cellular abnormal axon outgrowth: axonal tracts are thinner than in wild-type mice, especially for the tenth cranial nerve.
Breeding historyMixed, not congenic.
References
  • Retrograde signaling onto Ret during motor nerve terminal maturation.;Baudet Christel, Pozas Ester, Adameyko Igor, Andersson Elisabet, Ericson Johan, Ernfors Patrik, ;2008;The Journal of neuroscience : the official journal of the Society for Neuroscience;28;963-75; 18216204
  • Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain.;Pattyn Alexandre, Vallstedt Anna, Dias Jose M, Sander Maike, Ericson Johan, ;2003;Development (Cambridge, England);130;4149-59; 12874134
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreKarolinska Institutet, Stockholm, Sweden

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • NKX6-2-related autosomal recessive hypomyelinating leukodystrophy / Orphanet_527497

Literature references

  • Retrograde signaling onto Ret during motor nerve terminal maturation.;Baudet Christel, Pozas Ester, Adameyko Igor, Andersson Elisabet, Ericson Johan, Ernfors Patrik, ;2008;The Journal of neuroscience : the official journal of the Society for Neuroscience;28;963-75; 18216204
  • Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain.;Pattyn Alexandre, Vallstedt Anna, Dias Jose M, Sander Maike, Ericson Johan, ;2003;Development (Cambridge, England);130;4149-59; 12874134

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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