- decreased circulating LDL cholesterol level / IMPC
- decreased circulating HDL cholesterol level / IMPC
- decreased body weight / IMPC
- decreased circulating alanine transaminase level / IMPC
- decreased circulating cholesterol level / IMPC
- decreased circulating serum albumin level / IMPC
- decreased circulating total protein level / IMPC
- decreased lactate dehydrogenase level / IMPC
- preweaning lethality, complete penetrance / IMPC
B6Brd;B6N-Tyrc-Brd Sptbn1tm1a(EUCOMM)Wtsi/WtsiH
Status | Available to order |
EMMA ID | EM:06042 |
International strain name | B6Brd;B6N-Tyrc-Brd Sptbn1tm1a(EUCOMM)Wtsi/WtsiH |
Alternative name | EPD0065_1_F10 |
Strain type | Targeted Mutant Strains |
Allele/Transgene symbol | Sptbn1tm1a(EUCOMM)Wtsi, |
Gene/Transgene symbol | Sptbn1 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
Provider | Wellcome Trust Sanger Institute |
Provider affiliation | Wellcome Trust Sanger Institute |
Genetic information | This mouse line originates from EUCOMM ES clone EPD0065_1_F10. For further details on the construction of this clone see the page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Animals used for archiving | heterozygous C57BL/6NTac |
Breeding at archiving centre | Frozen samples received. No breeding at archiving centre. Due to the possible presence of C57BL/6J-Tyrc-Brd, may produce albino pups. |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Non-specific syndromic intellectual disability / Orphanet_528084
IMPC phenotypes (allele matching)
MGI phenotypes (allele matching)
- decreased circulating LDL cholesterol level / MGI
- decreased circulating HDL cholesterol level / MGI
- decreased body weight / MGI
- decreased circulating alanine transaminase level / MGI
- decreased circulating cholesterol level / MGI
- decreased circulating serum albumin level / MGI
- decreased circulating total protein level / MGI
- decreased lactate dehydrogenase level / MGI
- abnormal heart development / MGI
- edema / MGI
- hemorrhage / MGI
- small heart / MGI
- decreased mitotic index / MGI
- abnormal fetal cardiomyocyte morphology / MGI
- ventricular septal defect / MGI
- myocardial trabeculae hypoplasia / MGI
- thin ventricle myocardium compact layer / MGI
- absent coronary vessels / MGI
- increased fetal cardiomyocyte apoptosis / MGI
- decreased fetal cardiomyocyte proliferation / MGI
- abnormal heart ventricle wall thickness / MGI
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