- decreased level of surface class I molecules / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased IgG level / MGI
- abnormal pancreas morphology / MGI
- decreased susceptibility to bacterial infection / MGI
- increased IgM level / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- decreased circulating serum albumin level / MGI
- increased T-helper 1 cell number / MGI
- abnormal interleukin level / MGI
- abnormal tumor necrosis factor level / MGI
- increased susceptibility to infection induced morbidity/mortality / MGI
- absent CD8-positive, alpha-beta T cells / MGI
- abnormal pancreatic beta cell morphology / MGI
- abnormal T cell number / MGI
- insulitis / MGI
- absent CD4-positive, alpha beta T cells / MGI
- decreased T cell proliferation / MGI
- abnormal CD4-positive, alpha-beta T cell physiology / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- abnormal neuron proliferation / MGI
- abnormal immune system morphology / MGI
- abnormal spleen morphology / MGI
- abnormal immune system cell morphology / MGI
- postnatal growth retardation / MGI
- abnormal immune system physiology / MGI
- reduced fertility / MGI
- abnormal spleen periarteriolar lymphoid sheath morphology / MGI
- abnormal spleen marginal zone morphology / MGI
- abnormal CD4-positive, alpha beta T cell morphology / MGI
- abnormal T cell physiology / MGI
- abnormal B cell physiology / MGI
- abnormal immune system organ morphology / MGI
- abnormal cytokine secretion / MGI
- decreased susceptibility to parasitic infection / MGI
- increased susceptibility to parasitic infection / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- abnormal spleen B cell follicle morphology / MGI
- absent spleen germinal center / MGI
- decreased IgG1 level / MGI
- abnormal lymph node cell ratio / MGI
STOCK B2mtm1Unc Cd4tm1Litt H2-Ab1tm1Doi Tg(Cd4-CD4)2362Litt Tg(Cd4-EGFP) Tg(H2-Aa-HLA-DPA1)1Lone Tg(H2-Ab1-HLA-DPB1)1Lone Tg(HLA-A/H2-D/B2M)1Bpe/Orl
Status | Available to order |
EMMA ID | EM:06321 |
International strain name | STOCK B2mtm1Unc Cd4tm1Litt H2-Ab1tm1Doi Tg(Cd4-CD4)2362Litt Tg(Cd4-EGFP) Tg(H2-Aa-HLA-DPA1)1Lone Tg(H2-Ab1-HLA-DPB1)1Lone Tg(HLA-A/H2-D/B2M)1Bpe/Orl |
Alternative name | Hsurivong/CD4-EGFP |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(H2-Ab1-HLA-DPB1)1Lone, |
Gene/Transgene symbol | Tg(H2-Ab1-HLA-DPB1)1Lone |
Information from provider
Provider | Yu Chun LONE |
Provider affiliation | INSERM U1014 |
Genetic information | A transgenic construct containing an enhanced green florescent protein cDNA fused to the murine Cd4 promoter as described by Reifsnyder P & al (PubMed: 10570176) was injected into Hsurivong (EM:02221) mouse eggs. Founder line was then mated to Sure-L1 (EM:01783) mice until homozygous. |
Phenotypic information | HLA-A2+/+; HLA-DP4+/+; IAbeta°/°; Beta2m°/°; mCD4°/°; hCD4+/+; CD4-GFP+/+ |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | yes |
Immunocompromised | no |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | homozygous C57BL/6J, homozygous C57BL/6J |
Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Immunodeficiency by defective expression of MHC class I / Orphanet_34592
- Variant ABeta2M amyloidosis / Orphanet_314652
MGI phenotypes (allele matching)
Literature references
- Development of a humanized HLA-A2.1/DP4 transgenic mouse model and the use of this model to map HLA-DP4-restricted epitopes of HBV envelope protein.;Ru Zhitao, Xiao Wenjun, Pajot Anthony, Kou Zhihua, Sun Shihui, Maillere Bernard, Zhao Guangyu, Ojcius David M, Lone Yu-Chun, Zhou Yusen, ;2012;PloS one;7;e32247; 22403638
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