STOCK B2mtm1Unc Cd4tm1Litt H2-Ab1tm1Doi Tg(Cd4-CD4)2362Litt Tg(Cd4-EGFP) Tg(H2-Aa-HLA-DPA1)1Lone Tg(H2-Ab1-HLA-DPB1)1Lone Tg(HLA-A/H2-D/B2M)1Bpe/Orl

Status

Available to order

EMMA IDEM:06321
International strain nameSTOCK B2mtm1Unc Cd4tm1Litt H2-Ab1tm1Doi Tg(Cd4-CD4)2362Litt Tg(Cd4-EGFP) Tg(H2-Aa-HLA-DPA1)1Lone Tg(H2-Ab1-HLA-DPB1)1Lone Tg(HLA-A/H2-D/B2M)1Bpe/Orl
Alternative nameHsurivong/CD4-EGFP
Strain typeTransgenic Strains
Allele/Transgene symbolTg(H2-Ab1-HLA-DPB1)1Lone,
Gene/Transgene symbolTg(H2-Ab1-HLA-DPB1)1Lone

Information from provider

ProviderYu Chun LONE
Provider affiliationINSERM U1014
Genetic informationA transgenic construct containing an enhanced green florescent protein cDNA fused to the murine Cd4 promoter as described by Reifsnyder P & al (PubMed: 10570176) was injected into Hsurivong (EM:02221) mouse eggs. Founder line was then mated to Sure-L1 (EM:01783) mice until homozygous.
Phenotypic informationHLA-A2+/+; HLA-DP4+/+; IAbeta°/°; Beta2m°/°; mCD4°/°; hCD4+/+; CD4-GFP+/+
References
  • Development of a humanized HLA-A2.1/DP4 transgenic mouse model and the use of this model to map HLA-DP4-restricted epitopes of HBV envelope protein.;Ru Zhitao, Xiao Wenjun, Pajot Anthony, Kou Zhihua, Sun Shihui, Maillere Bernard, Zhao Guangyu, Ojcius David M, Lone Yu-Chun, Zhou Yusen, ;2012;PloS one;7;e32247; 22403638
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredyes
Immunocompromisedno

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivinghomozygous C57BL/6J, homozygous C57BL/6J
Stage of embryos2-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • decreased level of surface class I molecules / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased IgG level / MGI
  • abnormal pancreas morphology / MGI
  • decreased susceptibility to bacterial infection / MGI
  • increased IgM level / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • decreased circulating serum albumin level / MGI
  • increased T-helper 1 cell number / MGI
  • abnormal interleukin level / MGI
  • abnormal tumor necrosis factor level / MGI
  • increased susceptibility to infection induced morbidity/mortality / MGI
  • absent CD8-positive, alpha-beta T cells / MGI
  • abnormal pancreatic beta cell morphology / MGI
  • abnormal T cell number / MGI
  • insulitis / MGI
  • absent CD4-positive, alpha beta T cells / MGI
  • decreased T cell proliferation / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • abnormal neuron proliferation / MGI
  • abnormal immune system morphology / MGI
  • abnormal spleen morphology / MGI
  • abnormal immune system cell morphology / MGI
  • postnatal growth retardation / MGI
  • abnormal immune system physiology / MGI
  • reduced fertility / MGI
  • abnormal spleen periarteriolar lymphoid sheath morphology / MGI
  • abnormal spleen marginal zone morphology / MGI
  • abnormal CD4-positive, alpha beta T cell morphology / MGI
  • abnormal T cell physiology / MGI
  • abnormal B cell physiology / MGI
  • abnormal immune system organ morphology / MGI
  • abnormal cytokine secretion / MGI
  • decreased susceptibility to parasitic infection / MGI
  • increased susceptibility to parasitic infection / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • abnormal spleen B cell follicle morphology / MGI
  • absent spleen germinal center / MGI
  • decreased IgG1 level / MGI
  • abnormal lymph node cell ratio / MGI

Literature references

  • Development of a humanized HLA-A2.1/DP4 transgenic mouse model and the use of this model to map HLA-DP4-restricted epitopes of HBV envelope protein.;Ru Zhitao, Xiao Wenjun, Pajot Anthony, Kou Zhihua, Sun Shihui, Maillere Bernard, Zhao Guangyu, Ojcius David M, Lone Yu-Chun, Zhou Yusen, ;2012;PloS one;7;e32247; 22403638

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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