- decreased level of surface class I molecules / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased IgG level / MGI
- abnormal pancreas morphology / MGI
- decreased susceptibility to bacterial infection / MGI
- increased IgM level / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- decreased circulating serum albumin level / MGI
- increased T-helper 1 cell number / MGI
- abnormal interleukin level / MGI
- abnormal tumor necrosis factor level / MGI
- increased susceptibility to infection induced morbidity/mortality / MGI
- absent CD8-positive, alpha-beta T cells / MGI
- abnormal pancreatic beta cell morphology / MGI
- abnormal T cell number / MGI
- insulitis / MGI
- abnormal neuron proliferation / MGI
- abnormal immune system morphology / MGI
- abnormal spleen morphology / MGI
- abnormal immune system cell morphology / MGI
- postnatal growth retardation / MGI
- abnormal immune system physiology / MGI
- reduced fertility / MGI
- abnormal spleen periarteriolar lymphoid sheath morphology / MGI
- abnormal spleen marginal zone morphology / MGI
- abnormal CD4-positive, alpha beta T cell morphology / MGI
- abnormal T cell physiology / MGI
- abnormal B cell physiology / MGI
- abnormal immune system organ morphology / MGI
- abnormal cytokine secretion / MGI
- decreased susceptibility to parasitic infection / MGI
- increased susceptibility to parasitic infection / MGI
- abnormal CD4-positive, alpha-beta T cell physiology / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- abnormal spleen B cell follicle morphology / MGI
- absent spleen germinal center / MGI
- decreased IgG1 level / MGI
- abnormal lymph node cell ratio / MGI
- abnormal estrous cycle / MGI
- abnormal maternal decidual layer morphology / MGI
- reproductive system phenotype / MGI
- absent uterine NK cells / MGI
- prolonged estrous cycle / MGI
- prolonged diestrus / MGI
- prolonged metestrus / MGI
- abnormal placenta metrial gland morphology / MGI
- abnormal decidua basalis morphology / MGI
- increased granulocyte number / MGI
- spleen hypoplasia / MGI
- decreased body size / MGI
- arrested B cell differentiation / MGI
- decreased IgM level / MGI
- thymus hypoplasia / MGI
- arrested T cell differentiation / MGI
- increased susceptibility to infection / MGI
- abnormal effector T cell morphology / MGI
- increased natural killer cell mediated cytotoxicity / MGI
- decreased double-positive T cell number / MGI
- increased macrophage cell number / MGI
- lymph node hypoplasia / MGI
- absent mature B cells / MGI
- abnormal T cell receptor V(D)J recombination / MGI
- abnormal immunoglobulin V(D)J recombination / MGI
- decreased thymocyte number / MGI
- lung inflammation / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal macrophage physiology / MGI
- colitis / MGI
- abnormal T-helper 1 physiology / MGI
- abnormal response to transplant / MGI
- abnormal interferon secretion / MGI
- abnormal chemokine secretion / MGI
- decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
- abnormal intestinal mucosa morphology / MGI
- abnormal B cell morphology / MGI
- decreased double-negative T cell number / MGI
- increased double-negative T cell number / MGI
- decreased susceptibility to type IV hypersensitivity reaction / MGI
- abnormal stomach mucosa morphology / MGI
- abnormal intestinal epithelium morphology / MGI
- abnormal B cell number / MGI
- decreased pre-B cell number / MGI
- decreased mature B cell number / MGI
- increased immature B cell number / MGI
- decreased immature B cell number / MGI
- abnormal gamma-delta T cell differentiation / MGI
STOCK Rag2tm1Fwa B2mtm1Unc H2-Ab1tm1Doi Il2rgtm1Sug Tg(HLA-A/H2-D/B2M)1Bpe Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dma/Orl
Status | Available to order |
EMMA ID | EM:06326 |
International strain name | STOCK Rag2tm1Fwa B2mtm1Unc H2-Ab1tm1Doi Il2rgtm1Sug Tg(HLA-A/H2-D/B2M)1Bpe Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dma/Orl |
Alternative name | SURE-L1/Rag2°/°GammaC°/° |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dma |
Gene/Transgene symbol | Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dma |
Information from provider
Provider | Yu Chun LONE |
Provider affiliation | INSERM U1014 |
Genetic information | Sure-L1 (EM:01783) line was additionally knocked-out in Rag2 and Il2rg (gammaC) genes. |
Phenotypic information | HLA-A2+/+; DR1+/+; IAbeta°/°; Rag2°/°; GammaC°/° |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | yes |
Immunocompromised | yes |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | homozygous C57BL/6J, homozygous C57BL/6J |
Breeding at archiving centre | Animals are transgenic for Tg(HLA-A/H2-D/B2M)1Bpe (HLA-A2) and Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dma (DR1), homozygous knock-out for H2-Ab1 (IAbeta), Rag2 and Il2rg (GammaC), heterozygous knock-out for B2m (Beta2m). |
Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Omenn syndrome / Orphanet_39041
- T-B+ severe combined immunodeficiency due to gamma chain deficiency / Orphanet_276
- Immunodeficiency by defective expression of MHC class I / Orphanet_34592
- Variant ABeta2M amyloidosis / Orphanet_314652
- Severe combined immunodeficiency due to complete RAG1/2 deficiency / Orphanet_331206
- Combined immunodeficiency with granulomatosis / Orphanet_157949
MGI phenotypes (allele matching)
Literature references
- A mouse model of human adaptive immune functions: HLA-A2.1-/HLA-DR1-transgenic H-2 class I-/class II-knockout mice.;Pajot Anthony, Michel Marie-Louise, Fazilleau Nicolas, Pancré Véronique, Auriault Claude, Ojcius David M, Lemonnier François A, Lone Yu-Chun, ;2004;European journal of immunology;34;3060-9; 15468058
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).