- increased susceptibility to bacterial infection / MGI
- abnormal CD4-positive, alpha beta T cell morphology / MGI
- abnormal T-helper 1 cell differentiation / MGI
- abnormal spleen morphology / MGI
- enlarged spleen / MGI
- enlarged lymph nodes / MGI
- abnormal immune system cell morphology / MGI
- abnormal immune system physiology / MGI
- arrested B cell differentiation / MGI
- abnormal B cell differentiation / MGI
- altered tumor susceptibility / MGI
- abnormal lymph node morphology / MGI
- increased susceptibility to viral infection / MGI
- decreased immunoglobulin level / MGI
- increased lymphocyte cell number / MGI
- decreased B cell proliferation / MGI
- decreased T cell proliferation / MGI
- immune system phenotype / MGI
- absent plasma cells / MGI
- decreased dendritic cell number / MGI
- absent spleen germinal center / MGI
- absent lymph node germinal center / MGI
- decreased plasmacytoid dendritic cell number / MGI
B6.129P2-Irf4tm1Mak/Cnbc
Status | Available to order |
EMMA ID | EM:06742 |
International strain name | B6.129P2-Irf4tm1Mak/Cnbc |
Alternative name | Irf4 |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Irf4tm1Mak, |
Gene/Transgene symbol | Irf4 |
Information from provider
Provider | Tak W Mak |
Provider affiliation | Mak Lab, Campbell Family Breast Cancer reseach Institute |
Genetic information | Exons 2 and 3 replaced with neomycin resistance gene. |
Phenotypic information | Irf4 deficient mice develop progressive Lymphadenopathy, reduction in serum immunoglobulin concentrations, do not mount detectable antibody response, T lymphocyte function impaired. |
Breeding history | Backcrossed to C57BL/6 10 times. Bred as heterozygous. |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | yes |
Information from EMMA
Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Animals used for archiving | heterozygous C57BL/6J |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Whipple disease / Orphanet_3452
MGI phenotypes (allele matching)
Literature references
- Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function.;Mittrücker H W, Matsuyama T, Grossman A, Kündig T M, Potter J, Shahinian A, Wakeham A, Patterson B, Ohashi P S, Mak T W, ;1997;Science (New York, N.Y.);275;540-3; 8999800
- Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation.;Bollig Nadine, Brüstle Anne, Kellner Kerstin, Ackermann Waltraud, Abass Elfadil, Raifer Hartmann, Camara Bärbel, Brendel Cornelia, Giel Gavin, Bothur Evita, Huber Magdalena, Paul Christoph, Elli Alexandra, Kroczek Richard A, Nurieva Roza, Dong Chen, Jacob Ralf, Mak Tak W, Lohoff Michael, ;2012;Proceedings of the National Academy of Sciences of the United States of America;109;8664-9; 22552227
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