B6.129P2-Irf4tm1Mak/Cnbc

Status

Available to order

EMMA IDEM:06742
International strain nameB6.129P2-Irf4tm1Mak/Cnbc
Alternative nameIrf4
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolIrf4tm1Mak,
Gene/Transgene symbolIrf4

Information from provider

ProviderTak W Mak
Provider affiliationMak Lab, Campbell Family Breast Cancer reseach Institute
Genetic informationExons 2 and 3 replaced with neomycin resistance gene.
Phenotypic informationIrf4 deficient mice develop progressive Lymphadenopathy, reduction in serum immunoglobulin concentrations, do not mount detectable antibody response, T lymphocyte function impaired.
Breeding historyBackcrossed to C57BL/6 10 times. Bred as heterozygous.
References
  • Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function.;Mittrücker H W, Matsuyama T, Grossman A, Kündig T M, Potter J, Shahinian A, Wakeham A, Patterson B, Ohashi P S, Mak T W, ;1997;Science (New York, N.Y.);275;540-3; 8999800
  • Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation.;Bollig Nadine, Brüstle Anne, Kellner Kerstin, Ackermann Waltraud, Abass Elfadil, Raifer Hartmann, Camara Bärbel, Brendel Cornelia, Giel Gavin, Bothur Evita, Huber Magdalena, Paul Christoph, Elli Alexandra, Kroczek Richard A, Nurieva Roza, Dong Chen, Jacob Ralf, Mak Tak W, Lohoff Michael, ;2012;Proceedings of the National Academy of Sciences of the United States of America;109;8664-9; 22552227
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedyes

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivingheterozygous C57BL/6J

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • increased susceptibility to bacterial infection / MGI
  • abnormal CD4-positive, alpha beta T cell morphology / MGI
  • abnormal T-helper 1 cell differentiation / MGI
  • abnormal spleen morphology / MGI
  • enlarged spleen / MGI
  • enlarged lymph nodes / MGI
  • abnormal immune system cell morphology / MGI
  • abnormal immune system physiology / MGI
  • arrested B cell differentiation / MGI
  • abnormal B cell differentiation / MGI
  • altered tumor susceptibility / MGI
  • abnormal lymph node morphology / MGI
  • increased susceptibility to viral infection / MGI
  • decreased immunoglobulin level / MGI
  • increased lymphocyte cell number / MGI
  • decreased B cell proliferation / MGI
  • decreased T cell proliferation / MGI
  • immune system phenotype / MGI
  • absent plasma cells / MGI
  • decreased dendritic cell number / MGI
  • absent spleen germinal center / MGI
  • absent lymph node germinal center / MGI
  • decreased plasmacytoid dendritic cell number / MGI

Literature references

  • Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function.;Mittrücker H W, Matsuyama T, Grossman A, Kündig T M, Potter J, Shahinian A, Wakeham A, Patterson B, Ohashi P S, Mak T W, ;1997;Science (New York, N.Y.);275;540-3; 8999800
  • Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation.;Bollig Nadine, Brüstle Anne, Kellner Kerstin, Ackermann Waltraud, Abass Elfadil, Raifer Hartmann, Camara Bärbel, Brendel Cornelia, Giel Gavin, Bothur Evita, Huber Magdalena, Paul Christoph, Elli Alexandra, Kroczek Richard A, Nurieva Roza, Dong Chen, Jacob Ralf, Mak Tak W, Lohoff Michael, ;2012;Proceedings of the National Academy of Sciences of the United States of America;109;8664-9; 22552227

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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