B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Ddx5tm1.1Arte/ArteH
| Status | Available to order |
| EMMA ID | EM:06817 |
| International strain name | B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Ddx5tm1.1Arte/ArteH |
| Alternative name | C57BL/6: DDX5(p68) conditional knockout |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Gt(ROSA)26Sortm9(cre/ESR1)Arte, |
| Gene/Transgene symbol | Gt(ROSA)26Sor |
Information from provider
| Provider | Frances Fuller-Pace |
| Provider affiliation | Division of Cancer Research, University of Dundee |
| Genetic information | Tamoxifen-inducible Ddx5 (p68) knockout: C57BL/6-p68tm1303_133.1 Arte -Tg(ACTB-Flpe)2Arte -Gt(ROSA)26Sortm9(Cre/ESR)Arte |
| Phenotypic information | Mouse strain has no detectable phenotype in the absence of activated cre recombinase. Tamoxifen treatment induces p68 (Ddx5) knockout in multiple tissues; this results in hypo-plastic bone marrow and alterations in tissue organisation in the large intestine of a high proportion of mice. However we have only been able to perform short term experiments. These mice would be ideal for the generation of tissue-specific p68 knockout models. |
| Breeding history | It can be bred homozygously or heterozygously. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- The RNA helicase p68 (DDX5) is selectively required for the induction of p53-dependent p21 expression and cell-cycle arrest after DNA damage.;Nicol S M, Bray S E, Black H Derek, Lorimore S A, Wright E G, Lane D P, Meek D W, Coates P J, Fuller-Pace F V, ;2013;Oncogene;32;3461-9; 22986526