B6.Cg-Tg(Slc16a1-Luc)50Rttr/H

Status

Available to order

EMMA IDEM:06818
International strain nameB6.Cg-Tg(Slc16a1-Luc)50Rttr/H
Alternative nameMct1-Luc
Strain typeTransgenic Strains
Allele/Transgene symbolTg(Slc16a1-luc)50Rttr,
Gene/Transgene symbolTg(Slc16a1-luc)50Rttr

Information from provider

ProviderGuy Rutter
Provider affiliationSection of Cell Biology, Department of Medicine, Imperial College London
Genetic informationTransgenic mouse capable of tetracycline-inducible expression of Mct1 (Slc16a1) and firefly luciferase, when crossed with a tTA or rtTA expressing strain.
Phenotypic informationWhen expressed in pancreatic beta cells it renders insulin secretion sensitive to pyruvate and prevents the normal inhibition of insulin secretion induced by exercise, replicating the key features of Exercise-Induced Hyperinsulinism.
Breeding historyFounders have been backcrossed 7 times to C57BL/6 mice. Currently maintained either as heterozygotes crossed with C57BL/6 or as homozygotes crossed with each other.
References
  • Overexpression of monocarboxylate transporter-1 (SLC16A1) in mouse pancreatic β-cells leads to relative hyperinsulinism during exercise.;Pullen Timothy J, Sylow Lykke, Sun Gao, Halestrap Andrew P, Richter Erik A, Rutter Guy A, ;2012;Diabetes;61;1719-25; 22522610
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Literature references

  • Overexpression of monocarboxylate transporter-1 (SLC16A1) in mouse pancreatic β-cells leads to relative hyperinsulinism during exercise.;Pullen Timothy J, Sylow Lykke, Sun Gao, Halestrap Andrew P, Richter Erik A, Rutter Guy A, ;2012;Diabetes;61;1719-25; 22522610

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

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