C57BL/6N-Atm1Brd Jak1tm1a(EUCOMM)Hmgu/Biat
| Status | Available to order |
| EMMA ID | EM:06879 |
| International strain name | C57BL/6N-Atm1Brd Jak1tm1a(EUCOMM)Hmgu/Biat |
| Alternative name | C57BL/6N-A-Jak1tm1a(EUCOMM)Hmgu |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Jak1tm1a(EUCOMM)Hmgu, |
| Gene/Transgene symbol | Jak1 |
Information from provider
| Provider | Alexander Dohnal |
| Provider affiliation | Tumor Immunology, St. Anna Kinderkrebsforschung |
| Genetic information | The L1L2_Bact_P cassette was inserted at position 101192170 of chromosome 4 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 101191044. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre recombinase expression results in a knock-out mouse. If cre expression occurs without flp expression, a reporter knock-out mouse will be created. Further information on targeting strategies used for this and other EUCOMM/KOMP alleles can be found here. |
| Phenotypic information | not available |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive mendelian susceptibility to mycobacterial diseases due to partial JAK1 deficiency / Orphanet_574957
Literature references
- Loss of JAK1 Drives Innate Immune Deficiency.;Witalisz-Siepracka Agnieszka, Klein Klara, Prinz Daniela, Leidenfrost Nicoletta, Schabbauer Gernot, Dohnal Alexander, Sexl Veronika, ;2018;Frontiers in immunology;9;3108; 30671064