- decreased inflammatory response / MGI
- decreased neuron apoptosis / MGI
- abnormal response/metabolism to endogenous compounds / MGI
- abnormal microglial cell physiology / MGI
- decreased susceptibility to kidney reperfusion injury / MGI
- increased renal glomerular filtration rate / MGI
- decreased circulating creatinine level / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- decreased renal tubule apoptosis / MGI
- immune system phenotype / MGI
- enhanced wound healing / MGI
- decreased susceptibility to injury / MGI
- decreased cell proliferation / MGI
- skin hyperplasia / MGI
- decreased susceptibility to dopaminergic neuron neurotoxicity / MGI
129S-Parp1tm1Zqw/Cnrm
Status | Available to order |
EMMA ID | EM:00007 |
International strain name | 129S-Parp1tm1Zqw/Cnrm |
Alternative name | Adprt(Parp)-KO |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Parp1tm1Zqw, |
Gene/Transgene symbol | Parp1 |
Information from provider
Provider | Erwin Wagner |
Provider affiliation | IMP-Research Inst. Molecular Pathology Wien |
Genetic information | Direct gene inactivation generating a null mutation, see Wang et al., 1995, Genes & Development 9, 509-520. |
Phenotypic information | Susceptibility to skin disease. Oncogenesis, genomic stability and apoptosis models. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.;Wang Z Q, Auer B, Stingl L, Berghammer H, Haidacher D, Schweiger M, Wagner E F, ;1995;Genes & development;9;509-20; 7698643
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