STOCK Nebtm1(cre)Chen/Cnrm

Status

Available to order

EMMA IDEM:07145
International strain nameSTOCK Nebtm1(cre)Chen/Cnrm
Alternative nameNebulin knockout
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolNebtm1(cre)Chen,
Gene/Transgene symbolNeb

Information from provider

ProviderMarie-Louise Bang
Provider affiliationUniversity of California San Diego
Genetic informationKnockout of nebulin.
Phenotypic informationNebulin knockout mice die postnatally around day 10 and exhibit severe growth retardation, progressive muscle degradation, Z-line misalignment, and reduced thin filament length.
Breeding historyThe chimeric mice were crossed with Black Swiss mice to achieve germline transmission and were subsequently crossed once more with Black Swiss mice. After that they were kept in the mixed background.
References
  • Nebulin-deficient mice exhibit shorter thin filament lengths and reduced contractile function in skeletal muscle.;Bang Marie-Louise, Li Xiaodong, Littlefield Ryan, Bremner Shannon, Thor Andrea, Knowlton Kirk U, Lieber Richard L, Chen Ju, ;2006;The Journal of cell biology;173;905-16; 16769824
  • Nebulin plays a direct role in promoting strong actin-myosin interactions.;Bang Marie-Louise, Caremani Marco, Brunello Elisabetta, Littlefield Ryan, Lieber Richard L, Chen Ju, Lombardi Vincenzo, Linari Marco, ;2009;FASEB journal : official publication of the Federation of American Societies for Experimental Biology;23;4117-25; 19679637
  • Reduced thin filament length in nebulin-knockout skeletal muscle alters isometric contractile properties.;Gokhin David S, Bang Marie-Louise, Zhang Jianlin, Chen Ju, Lieber Richard L, ;2009;American journal of physiology. Cell physiology;296;C1123-32; 19295172
Homozygous fertileno
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • decreased body weight / MGI
  • abnormal suckling behavior / MGI
  • abnormal muscle fiber morphology / MGI
  • abnormal sarcomere morphology / MGI
  • abnormal Z lines / MGI
  • muscle phenotype / MGI
  • decreased total body fat amount / MGI
  • postnatal lethality, complete penetrance / MGI

Literature references

  • Nebulin-deficient mice exhibit shorter thin filament lengths and reduced contractile function in skeletal muscle.;Bang Marie-Louise, Li Xiaodong, Littlefield Ryan, Bremner Shannon, Thor Andrea, Knowlton Kirk U, Lieber Richard L, Chen Ju, ;2006;The Journal of cell biology;173;905-16; 16769824
  • Nebulin plays a direct role in promoting strong actin-myosin interactions.;Bang Marie-Louise, Caremani Marco, Brunello Elisabetta, Littlefield Ryan, Lieber Richard L, Chen Ju, Lombardi Vincenzo, Linari Marco, ;2009;FASEB journal : official publication of the Federation of American Societies for Experimental Biology;23;4117-25; 19679637
  • Reduced thin filament length in nebulin-knockout skeletal muscle alters isometric contractile properties.;Gokhin David S, Bang Marie-Louise, Zhang Jianlin, Chen Ju, Lieber Richard L, ;2009;American journal of physiology. Cell physiology;296;C1123-32; 19295172

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