C57BL/6N-Tg(Tnfrsf19-cre/ERT2)1Kori/Ph

Status	Available to order
EMMA ID	EM:07327
International strain name	C57BL/6N-Tg(Tnfrsf19-cre/ERT2)1Kori/Ph
Alternative name	TROY-CreERT2
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Tnfrsf19-cre/ERT2)1Kori,
Gene/Transgene symbol	Tg(Tnfrsf19-cre/ERT2)1Kori

Information from provider

Provider	Vladimir Korinek
Provider affiliation	Cell and Developmental Biology, Institute of Molecular Genetics of the ASCR, v. v. i.
Genetic information	C57BL/6N mouse oocytes were injected by RP23-166C22 BAC DNA containing whole Tnfrsf19 (Troy) gene with 65, 88 kbp overhangs on 5', 3' ends, respectively. CreERT2 coding sequence is incorporated into translation initiating ATG of second exon of Tnfrsf19 gene. These mice should provide an insight to importance of Tnfrsf19 gene in context of Wnt signaling. This will be achievable after crossbreeding with either loxP reporter mice or another loxP mouse which will ablates Wnt signaling in cells where Cre recombinase is expressed.
Phenotypic information	The mouse strain does not show specific phenotype.
Breeding history	Mouse strain is kept on heterozygous basis. Transgenic animals are crossed with C57BL/6N partners.
References	Troy, a tumor necrosis factor receptor family member, interacts with lgr5 to inhibit wnt signaling in intestinal stem cells.;Fafilek Bohumil, Krausova Michaela, Vojtechova Martina, Pospichalova Vendula, Tumova Lucie, Sloncova Eva, Huranova Martina, Stancikova Jitka, Hlavata Adela, Svec Jiri, Sedlacek Radislav, Luksan Ondrej, Oliverius Martin, Voska Ludek, Jirsa Milan, Paces Jan, Kolar Michal, Krivjanska Maria, Klimesova Klara, Tlaskalova-Hogenova Helena, Korinek Vladimir, ;2013;Gastroenterology;144;381-391; 23142137
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Institute of Molecular Genetics, Prague, Czech Republic

Literature references

Troy, a tumor necrosis factor receptor family member, interacts with lgr5 to inhibit wnt signaling in intestinal stem cells.;Fafilek Bohumil, Krausova Michaela, Vojtechova Martina, Pospichalova Vendula, Tumova Lucie, Sloncova Eva, Huranova Martina, Stancikova Jitka, Hlavata Adela, Svec Jiri, Sedlacek Radislav, Luksan Ondrej, Oliverius Martin, Voska Ludek, Jirsa Milan, Paces Jan, Kolar Michal, Krivjanska Maria, Klimesova Klara, Tlaskalova-Hogenova Helena, Korinek Vladimir, ;2013;Gastroenterology;144;381-391; 23142137

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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