129-Elanetm1(cre)Roes Ctsgtm1.1Roes/H
Status | Available to order |
EMMA ID | EM:00074 |
International strain name | 129-Elanetm1(cre)Roes Ctsgtm1.1Roes/H |
Alternative name | GECG |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Elanetm1(cre)Roes, |
Gene/Transgene symbol | Elane |
Information from provider
Provider | Jurgen Roes |
Provider affiliation | Windeyer Institute of Medical Sciences, University College London |
Genetic information | Double mutant generated by intercrossing Elane (Ela2)- and Ctsg-deficient mice. |
Phenotypic information | Impaired innate immunity. |
References |
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Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Cyclic neutropenia / Orphanet_2686
- Autosomal dominant severe congenital neutropenia / Orphanet_486
MGI phenotypes (allele matching)
Literature references
- Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G.;Tkalcevic J, Novelli M, Phylactides M, Iredale J P, Segal A W, Roes J, ;2000;Immunity;12;201-10; 10714686
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