129-Elanetm1(cre)Roes Ctsgtm1.1Roes/H

Status

Available to order

EMMA IDEM:00074
International strain name129-Elanetm1(cre)Roes Ctsgtm1.1Roes/H
Alternative nameGECG
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolElanetm1(cre)Roes,
Gene/Transgene symbolElane

Information from provider

ProviderJurgen Roes
Provider affiliationWindeyer Institute of Medical Sciences, University College London
Genetic informationDouble mutant generated by intercrossing Elane (Ela2)- and Ctsg-deficient mice.
Phenotypic informationImpaired innate immunity.
References
  • Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G.;Tkalcevic J, Novelli M, Phylactides M, Iredale J P, Segal A W, Roes J, ;2000;Immunity;12;201-10; 10714686

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • increased susceptibility to infection induced morbidity/mortality / MGI
  • decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • impaired neutrophil recruitment / MGI

Literature references

  • Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G.;Tkalcevic J, Novelli M, Phylactides M, Iredale J P, Segal A W, Roes J, ;2000;Immunity;12;201-10; 10714686

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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