MGI phenotypes (allele matching)
129-Elanetm1(cre)Roes/H
| Status | Available to order |
| EMMA ID | EM:00075 |
| International strain name | 129-Elanetm1(cre)Roes/H |
| Alternative name | GEcre |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Elanetm1(cre)Roes, |
| Gene/Transgene symbol | Elane |
Information from provider
| Provider | Jurgen Roes |
| Provider affiliation | Windeyer Institute of Medical Sciences, University College London |
| Genetic information | Insertion of the cre recombinase at the ATG of Elane (Ela2) gene sequence. |
| Phenotypic information | Impaired innate immunity. |
| References |
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Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Cyclic neutropenia / Orphanet_2686
- Autosomal dominant severe congenital neutropenia / Orphanet_486
Literature references
- Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G.;Tkalcevic J, Novelli M, Phylactides M, Iredale J P, Segal A W, Roes J, ;2000;Immunity;12;201-10; 10714686
- PD-L1 maintains neutrophil extracellular traps release by inhibiting neutrophil autophagy in endotoxin-induced lung injury.;Zhu Cheng-Long, Xie Jian, Zhao Zhen-Zhen, Li Peng, Liu Qiang, Guo Yu, Meng Yan, Wan Xiao-Jian, Bian Jin-Jun, Deng Xiao-Ming, Wang Jia-Feng, ;2022;Frontiers in immunology;13;949217; 36016930