B6;C-Tg(tetO-cre)LC1Bjd/BjdCnrm

Status

Available to order

EMMA IDEM:00753
International strain nameB6;C-Tg(tetO-cre)LC1Bjd/BjdCnrm
Alternative nameLC-1
Strain typeTransgenic Strains
Allele/Transgene symbolTg(tetO-cre)LC1Bjd,
Gene/Transgene symbolTg(tetO-cre)LC1Bjd

Information from provider

ProviderHermann Bujard
Provider affiliationZentrum für Molekulare Biologie Heidelberg- ZMBH
Genetic informationIn this strain both the luciferase (L) and the cre recombinase (C) genes with a nuclear localization signal are driven by a bidirectional, tetracycline-responsive promoter element (Ptet bi-1).
Phenotypic informationMating of the (tetO-cre)LC1 strain to a strain expressing the tetracycline-controlled activator proteins tTA or rtTA, coupled to a tissue-specific promoter, results in the expression of cre recombinase and luciferase proteins in the appropriate tissue and tetracycline-inducible fashion.
References
  • Stringent doxycycline dependent control of CRE recombinase in vivo.;Schönig Kai, Schwenk Frieder, Rajewsky Klaus, Bujard Hermann, ;2002;Nucleic acids research;30;e134; 12466566

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Literature references

  • Stringent doxycycline dependent control of CRE recombinase in vivo.;Schönig Kai, Schwenk Frieder, Rajewsky Klaus, Bujard Hermann, ;2002;Nucleic acids research;30;e134; 12466566
  • Depot formation of doxycycline impairs Tet-regulated gene expression in vivo.;Anders Kathleen, Buschow Christian, Charo Jehad, Blankenstein Thomas, ;2012;Transgenic research;21;1099-107; 22167485
  • A novel Axin2 knock-in mouse model for visualization and lineage tracing of WNT/CTNNB1 responsive cells.;van de Moosdijk Anoeska Agatha Alida, van de Grift Yorick Bernardus Cornelis, de Man Saskia Madelon Ada, Zeeman Amber Lisanne, van Amerongen Renée, ;2020;Genesis (New York, N.Y. : 2000);58;e23387; 32643876
  • Embryonic FAP+ lymphoid tissue organizer cells generate the reticular network of adult lymph nodes.;Denton Alice E, Carr Edward J, Magiera Lukasz P, Watts Andrew J B, Fearon Douglas T, ;2019;The Journal of experimental medicine;216;2242-2252; 31324739

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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