B6;C-Tg(tetO-cre)LC1Bjd/BjdCnrm
Status | Available to order |
EMMA ID | EM:00753 |
International strain name | B6;C-Tg(tetO-cre)LC1Bjd/BjdCnrm |
Alternative name | LC-1 |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(tetO-cre)LC1Bjd, |
Gene/Transgene symbol | Tg(tetO-cre)LC1Bjd |
Information from provider
Provider | Hermann Bujard |
Provider affiliation | Zentrum für Molekulare Biologie Heidelberg- ZMBH |
Genetic information | In this strain both the luciferase (L) and the cre recombinase (C) genes with a nuclear localization signal are driven by a bidirectional, tetracycline-responsive promoter element (Ptet bi-1). |
Phenotypic information | Mating of the (tetO-cre)LC1 strain to a strain expressing the tetracycline-controlled activator proteins tTA or rtTA, coupled to a tissue-specific promoter, results in the expression of cre recombinase and luciferase proteins in the appropriate tissue and tetracycline-inducible fashion. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Stringent doxycycline dependent control of CRE recombinase in vivo.;Schönig Kai, Schwenk Frieder, Rajewsky Klaus, Bujard Hermann, ;2002;Nucleic acids research;30;e134; 12466566
- Depot formation of doxycycline impairs Tet-regulated gene expression in vivo.;Anders Kathleen, Buschow Christian, Charo Jehad, Blankenstein Thomas, ;2012;Transgenic research;21;1099-107; 22167485
- A novel Axin2 knock-in mouse model for visualization and lineage tracing of WNT/CTNNB1 responsive cells.;van de Moosdijk Anoeska Agatha Alida, van de Grift Yorick Bernardus Cornelis, de Man Saskia Madelon Ada, Zeeman Amber Lisanne, van Amerongen Renée, ;2020;Genesis (New York, N.Y. : 2000);58;e23387; 32643876
- Embryonic FAP+ lymphoid tissue organizer cells generate the reticular network of adult lymph nodes.;Denton Alice E, Carr Edward J, Magiera Lukasz P, Watts Andrew J B, Fearon Douglas T, ;2019;The Journal of experimental medicine;216;2242-2252; 31324739
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