- decreased level of surface class I molecules / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased IgG level / MGI
- abnormal pancreas morphology / MGI
- decreased susceptibility to bacterial infection / MGI
- increased IgM level / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- decreased circulating serum albumin level / MGI
- increased T-helper 1 cell number / MGI
- abnormal interleukin level / MGI
- abnormal tumor necrosis factor level / MGI
- increased susceptibility to infection induced morbidity/mortality / MGI
- absent CD8-positive, alpha-beta T cells / MGI
- abnormal pancreatic beta cell morphology / MGI
- abnormal T cell number / MGI
- insulitis / MGI
- arrested T cell differentiation / MGI
- abnormal double-negative T cell morphology / MGI
- abnormal B cell morphology / MGI
- abnormal regulatory T cell physiology / MGI
- absent T cells / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- absent CD4-positive, alpha beta T cells / MGI
- increased CD4-positive, alpha beta T cell number / MGI
B6.Cg-B2mtm1Unc Cd3etm1Mal H2-K1tm1Bpe H2-D1tm1Bpe/Orl
Status | Available to order |
EMMA ID | EM:00754 |
International strain name | B6.Cg-B2mtm1Unc Cd3etm1Mal H2-K1tm1Bpe H2-D1tm1Bpe/Orl |
Alternative name | TetraKO - CD3- and MHC class I- |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | H2-K1tm1Bpe, |
Gene/Transgene symbol | H2-K1 |
Information from provider
Provider | Antonio Freitas |
Provider affiliation | Institut Pasteur |
Genetic information | Inactivation of the Cd3epsilon gene. Inactivation of the b allele of both D and K loci of the MHC class I molecules. Inactivation of the beta2-microglobulin gene. |
Phenotypic information | Lack of T lymphocytes and MHC class I molecules. |
References | None available |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Immunodeficiency by defective expression of MHC class I / Orphanet_34592
- Variant ABeta2M amyloidosis / Orphanet_314652
- T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta / Orphanet_169160
MGI phenotypes (allele matching)
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