B6.Cg-B2mtm1Unc Cd3etm1Mal H2-K1tm1Bpe H2-D1tm1Bpe/Orl

Status

Available to order

EMMA IDEM:00754
International strain nameB6.Cg-B2mtm1Unc Cd3etm1Mal H2-K1tm1Bpe H2-D1tm1Bpe/Orl
Alternative nameTetraKO - CD3- and MHC class I-
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolH2-K1tm1Bpe,
Gene/Transgene symbolH2-K1

Information from provider

ProviderAntonio Freitas
Provider affiliationInstitut Pasteur
Genetic informationInactivation of the Cd3epsilon gene. Inactivation of the b allele of both D and K loci of the MHC class I molecules. Inactivation of the beta2-microglobulin gene.
Phenotypic informationLack of T lymphocytes and MHC class I molecules.
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • decreased level of surface class I molecules / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased IgG level / MGI
  • abnormal pancreas morphology / MGI
  • decreased susceptibility to bacterial infection / MGI
  • increased IgM level / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • decreased circulating serum albumin level / MGI
  • increased T-helper 1 cell number / MGI
  • abnormal interleukin level / MGI
  • abnormal tumor necrosis factor level / MGI
  • increased susceptibility to infection induced morbidity/mortality / MGI
  • absent CD8-positive, alpha-beta T cells / MGI
  • abnormal pancreatic beta cell morphology / MGI
  • abnormal T cell number / MGI
  • insulitis / MGI
  • arrested T cell differentiation / MGI
  • abnormal double-negative T cell morphology / MGI
  • abnormal B cell morphology / MGI
  • abnormal regulatory T cell physiology / MGI
  • absent T cells / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • absent CD4-positive, alpha beta T cells / MGI
  • increased CD4-positive, alpha beta T cell number / MGI

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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