B6.129(Cg)-Pax2tm1Pgr/Kieg

Status

Available to order

EMMA IDEM:00776
International strain nameB6.129(Cg)-Pax2tm1Pgr/Kieg
Alternative nameB6.129(Cg)-Pax2/Kieg
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolPax2tm1Pgr,
Gene/Transgene symbolPax2

Information from provider

ProviderPeter Gruss
Provider affiliationMax Planck Inst. Biophysical Chemistry
Genetic informationThe Pax2 exon 1 and parts of exon 2 including the ATG are removed upon recombination of 4 kb genomic region 5' of exon 1 and 4 kb genomic region 3' of exon 2, flanking a neo-resistance cassette.
Phenotypic informationUrogenital defects, midbrain-hindbrain boundary affected, optic nerve dysplasia, optic coloboma, exencephalus.
Breeding historyMore than 10 backcrosses to C57BL/6.
References
  • Pax-2 controls multiple steps of urogenital development.;Torres M, Gómez-Pardo E, Dressler G R, Gruss P, ;1995;Development (Cambridge, England);121;4057-65; 8575306
  • Pax2 contributes to inner ear patterning and optic nerve trajectory.;Torres M, Gómez-Pardo E, Gruss P, ;1996;Development (Cambridge, England);122;3381-91; 8951055
  • Pax2/5 and Pax6 subdivide the early neural tube into three domains.;Schwarz M, Alvarez-Bolado G, Dressler G, Urbánek P, Busslinger M, Gruss P, ;1999;Mechanisms of development;82;29-39; 10354469
  • Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6.;Schwarz M, Cecconi F, Bernier G, Andrejewski N, Kammandel B, Wagner M, Gruss P, ;2000;Development (Cambridge, England);127;4325-34; 11003833

Information from EMMA

Archiving centreKarolinska Institutet, Stockholm, Sweden

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal inner ear morphology / MGI
  • abnormal cochlea morphology / MGI
  • decreased cochlear coiling / MGI
  • exencephaly / MGI
  • small kidney / MGI
  • renal hypoplasia / MGI
  • abnormal kidney calyx morphology / MGI
  • hearing/vestibular/ear phenotype / MGI
  • optic nerve coloboma / MGI
  • decreased nephron number / MGI
  • kidney cortex hypoplasia / MGI
  • decreased renal glomerulus number / MGI
  • abnormal organ of Corti morphology / MGI
  • abnormal stria vascularis morphology / MGI
  • abnormal semicircular canal morphology / MGI
  • absent cochlear ganglion / MGI
  • abnormal scala media morphology / MGI
  • abnormal cochlear sensory epithelium morphology / MGI
  • small vestibular ganglion / MGI
  • absent vestibular saccule / MGI
  • abnormal vestibular saccular macula morphology / MGI
  • abnormal common crus morphology / MGI
  • abnormal endolymphatic duct morphology / MGI
  • short endolymphatic duct / MGI
  • small endolymphatic duct / MGI
  • abnormal semicircular canal ampulla morphology / MGI
  • abnormal inner ear vestibule morphology / MGI
  • abnormal vestibular saccule morphology / MGI
  • abnormal utricle morphology / MGI
  • absent organ of Corti / MGI
  • absent kidney / MGI
  • abnormal kidney development / MGI
  • abnormal diencephalon morphology / MGI
  • incomplete rostral neuropore closure / MGI
  • abnormal testis morphology / MGI
  • abnormal eye development / MGI
  • abnormal optic nerve morphology / MGI
  • abnormal optic nerve innervation / MGI
  • abnormal brain morphology / MGI
  • absent cochlea / MGI
  • absent vagina / MGI
  • absent vas deferens / MGI
  • absent oviduct / MGI
  • absent seminal vesicle / MGI
  • abnormal axon extension / MGI
  • abnormal neural tube closure / MGI
  • absent ureter / MGI
  • abnormal optic tract morphology / MGI
  • abnormal optic stalk morphology / MGI
  • absent cochlear nerve / MGI
  • absent epididymis / MGI
  • absent efferent ductules of testis / MGI
  • abnormal retinal pigmentation / MGI
  • coloboma / MGI
  • Mullerian duct degeneration / MGI
  • short scala media / MGI
  • abnormal mesonephros morphology / MGI
  • Wolffian duct degeneration / MGI
  • rudimentary Wolffian ducts / MGI
  • rudimentary Mullerian ducts / MGI
  • absent uterine horn / MGI
  • absent optic chiasm / MGI
  • abnormal intermediate mesoderm / MGI
  • absent ureteric bud / MGI
  • abnormal metanephric mesenchyme morphology / MGI
  • abnormal mesonephric mesenchyme morphology / MGI
  • absent metanephros / MGI
  • abnormal optic fissure closure / MGI

Literature references

  • Pax-2 controls multiple steps of urogenital development.;Torres M, Gómez-Pardo E, Dressler G R, Gruss P, ;1995;Development (Cambridge, England);121;4057-65; 8575306
  • Pax2 contributes to inner ear patterning and optic nerve trajectory.;Torres M, Gómez-Pardo E, Gruss P, ;1996;Development (Cambridge, England);122;3381-91; 8951055
  • Pax2/5 and Pax6 subdivide the early neural tube into three domains.;Schwarz M, Alvarez-Bolado G, Dressler G, Urbánek P, Busslinger M, Gruss P, ;1999;Mechanisms of development;82;29-39; 10354469
  • Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6.;Schwarz M, Cecconi F, Bernier G, Andrejewski N, Kammandel B, Wagner M, Gruss P, ;2000;Development (Cambridge, England);127;4325-34; 11003833

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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