B6;129S4-Col1a1tm1(tetO-Vegfc)Mmul/Biat
| Status | Available to order |
| EMMA ID | EM:07833 |
| International strain name | B6;129S4-Col1a1tm1(tetO-Vegfc)Mmul/Biat |
| Alternative name | B6N;129P2-Col1a1tm1(tetO-VEGFC)Biat |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Col1a1tm1(tetO-Vegfc)Mmul, |
| Gene/Transgene symbol | Col1a1 |
Information from provider
| Provider | Mathias Mueller |
| Provider affiliation | Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna |
| Genetic information | KH2 ES cells were targeted with a construct harbouring the tetO followed by the Vegfc cDNA into the Col1a1 locus (downstream of the polyA). |
| Phenotypic information | Homozygous:There is no obvious phenotype.Heterozygous:Mice were kept so far heterozygous. |
| Breeding history | ES cells were injected into blastocysts and resulting chimeras were crossed to C57BL/6N females. Transgenic offspring were mated with wild-type offspring (non siblings). |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Ehlers-Danlos/osteogenesis imperfecta syndrome / Orphanet_230857
- Osteogenesis imperfecta type 3 / Orphanet_216812
- Arthrochalasia Ehlers-Danlos syndrome / Orphanet_1899
- Classical Ehlers-Danlos syndrome / Orphanet_287
- Osteogenesis imperfecta type 2 / Orphanet_216804
- Osteogenesis imperfecta type 4 / Orphanet_216820
- Caffey disease / Orphanet_1310
- High bone mass osteogenesis imperfecta / Orphanet_314029
- Osteogenesis imperfecta type 1 / Orphanet_216796