| Status | Available to order |
| EMMA ID | EM:08021 |
| International strain name | 129(Cg)-Tectatm4.1Gpr/GprH |
| Alternative name | Tecta |
| Strain type | Targeted Mutant Strains : Point mutation |
| Allele/Transgene symbol | Tectatm4.1Gpr, |
| Gene/Transgene symbol | Tecta |
| Provider | Guy Richardson |
| Provider affiliation | School of Life Sciences, University of Sussex |
| Genetic information | Exon 17 was replaced with one in which two point mutations (C>T and G>A) results in the amino acid substitutions of phenylalanine for leucine at position 1820 (L1820F) and aspartic acid for glycine at position 1824 (G1824D). Cre-mediated recombination was used to remove the neomycin resistance cassette after correct targeting was confirmed. |
| Phenotypic information | Homozygous:In Tecta |
| Breeding history | F1 mice from germline transmitting chimera were mated with a Cre deleter line to remove the floxed neomycin resistance cassette and the F2 generation then outbred to 129SvEv. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
