C57BL/6J-Tg(Nos2-tdTomato,-cre)1Albe/Orl
Status | Available to order |
EMMA ID | EM:08262 |
International strain name | C57BL/6J-Tg(Nos2-tdTomato,-cre)1Albe/Orl |
Alternative name | NOS2-Tomato-Cre |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(Nos2-tdTomato, -cre)1Albe |
Gene/Transgene symbol | Tg(Nos2-tdTomato,-cre)1Albe |
Information from provider
Provider | Bessis Bessis |
Provider affiliation | ER70 CNRS et Unite 125 Inserm |
Additional owner | Grégoire Lauvau, Albert Einstein College of Medecine, New York, U.S.A. and Frédéric Geissmann, King's College, London, UK |
Genetic information | A tdTomato-ires-Cre cassette was inserted by homologous recombination into the RP23-341J22 bacterial artificial chromosome (BAC). The cassette was inserted into exon 2 with the ATG of the tdTomato replacing the endogenous ATG. The recombined BAC was then used to generate the transgenic mouse. |
Phenotypic information | Homozygous:Express the tdTomato and cre recombinase in Nos2-positive cells.Heterozygous:Express the tdTomato and cre recombinase in Nos2-positive cells |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | heterozygous C57BL/6J |
Literature references
- NOS2 expression is restricted to neurons in the healthy brain but is triggered in microglia upon inflammation.;Béchade Catherine, Colasse Sabrina, Diana Marco A, Rouault Martin, Bessis Alain, ;2014;Glia;62;956-63; 24615726
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).