- absent T cells / MGI
- absent B cells / MGI
- absent CD8-positive, alpha-beta T cells / MGI
- absent CD4-positive, alpha beta T cells / MGI
- decreased double-positive T cell number / MGI
- immune system phenotype / MGI
- decreased pre-B cell number / MGI
- decreased DN1 thymic pro-T cell number / MGI
- decreased DN4 thymocyte number / MGI
C57BL/6-Dclre1cm1Brck/Flmg
Status | Available to order |
EMMA ID | EM:08361 |
International strain name | C57BL/6-Dclre1cm1Brck/Flmg |
Alternative name | Dclre1c |
Strain type | Spontaneous |
Allele/Transgene symbol | Dclre1cm1Brck, |
Gene/Transgene symbol | Dclre1c |
Information from provider
Provider | Thomas Brocker |
Provider affiliation | Institute for Immunology, Ludwig-Maximilians-Universität Munich |
Genetic information | Genomic deletion of 4035 base pairs in Dclre1c including exons 10 and 11 of this gene. |
Phenotypic information | Homozygous:Non leaky absence of B and T cells in the presence of NK cells.Heterozygous:no phenotype observed |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | yes |
Information from EMMA
Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
Animals used for archiving | homozygous C57BL/6, wild-type C57BL/6J |
Stage of embryos | Morula |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Severe combined immunodeficiency due to DCLRE1C deficiency / Orphanet_275
- Omenn syndrome / Orphanet_39041
MGI phenotypes (allele matching)
Literature references
- Novel spontaneous deletion of artemis exons 10 and 11 in mice leads to T- and B-cell deficiency.;Barthels Christian, Puchałka Jacek, Racek Tomas, Klein Christoph, Brocker Thomas, ;2013;PloS one;8;e74838; 24069355
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