MGI phenotypes (allele matching)
- immune system phenotype / MGI
B6.129-Prdm1tm2.1Liz/RobH
| Status | Available to order |
| EMMA ID | EM:08439 |
| International strain name | B6.129-Prdm1tm2.1Liz/RobH |
| Alternative name | Prdm1 ΔEx1B/ΔEx1B(Rob) |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Prdm1tm2.1Liz, |
| Gene/Transgene symbol | Prdm1 |
Information from provider
| Provider | Elizabeth Robertson |
| Provider affiliation | The Sir William Dunn School of Pathology, University of Oxford |
| Genetic information | A targeted deletion of a 3.9kb fragment from Prdm1 (chromosome 10: 44,247,021 to 44,250,926) containing the transcript exon 1B, a novel alternative first exon that splices directly to exon 3. This deletion generated an exon 1B null allele. |
| Phenotypic information | Homozygous:Mice with targeted exon 1B deletion have slightly decreased expression in the yolk sac but show no other noticeable effects in embryo or adult tissues.Heterozygous:No phenotype. |
| Breeding history | Exact number of generations backcrossed is unknown, but is more than 10. Exact number of generations sib-mated is unknown, but is more than 10 as, after backcrossing, they were maintained by intercrossing. Currently maintained as homozygous stock. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Literature references
- Blimp-1/Prdm1 alternative promoter usage during mouse development and plasma cell differentiation.;Morgan Marc A J, Magnusdottir Erna, Kuo Tracy C, Tunyaplin Chai, Harper James, Arnold Sebastian J, Calame Kathryn, Robertson Elizabeth J, Bikoff Elizabeth K, ;2009;Molecular and cellular biology;29;5813-27; 19737919