MGI phenotypes (allele matching)
B6.129-Prdm1tm3.1Liz/RobH
| Status | Available to order |
| EMMA ID | EM:08497 |
| International strain name | B6.129-Prdm1tm3.1Liz/RobH |
| Alternative name | Prdm1 tm5Rob |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Prdm1tm3.1Liz, |
| Gene/Transgene symbol | Prdm1 |
Information from provider
| Provider | Elizabeth Robertson |
| Provider affiliation | The Sir William Dunn School of Pathology, University of Oxford |
| Genetic information | The Prdm1 delta-ex7 allele results in targeted deletion of exon 7 sequences and expression of only the short isoform of Prdm1. |
| Phenotypic information | Homozygous:Prdm1 delta-ex7/delta-ex7 mice are embryonic lethal, and die at around E10.5 due to placental defects.Heterozygous:No observed phenotype in Prdm1 +/delta-ex7 mice. |
| Breeding history | N. of generations backcrossed is >10 |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Literature references
- Alternative splicing regulates Prdm1/Blimp-1 DNA binding activities and corepressor interactions.;Morgan Marc A J, Mould Arne W, Li Li, Robertson Elizabeth J, Bikoff Elizabeth K, ;2012;Molecular and cellular biology;32;3403-13; 22733990