C3;C-Emx2Pdo/H

Status

Available to order

EMMA IDEM:00085
International strain nameC3;C-Emx2Pdo/H
Alternative nameGENA181
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolEmx2Pdo,
Gene/Transgene symbolEmx2

Information from provider

ProviderNick Parkinson
Provider affiliationMRC Mammalian Genetics Unit
Phenotypic informationThese mice have a malformed ossicular chain in the middle ear which leads to conductive hearing loss. In addition, a developmental aberration in inner ear stereocilia patterning leads to an extra row of inner and outer hair cells and sensoneural deafness.
References
  • A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI phenotypes (allele matching)
  • abnormal malleus morphology / MGI
  • deafness / MGI
  • increased cochlear inner hair cell number / MGI
  • increased cochlear outer hair cell number / MGI
  • decreased cochlear nerve compound action potential / MGI
  • conductive hearing loss / MGI
  • sensorineural hearing loss / MGI
  • syndromic hearing loss / MGI
  • abnormal middle ear ossicle morphology / MGI
  • cardiovascular system phenotype / MGI
  • absent pinna reflex / MGI
  • abnormal incudostapedial joint morphology / MGI
  • abnormal incudomalleolar joint morphology / MGI
  • abnormal incus long process morphology / MGI
  • absent incus lenticular process / MGI
  • abnormal stapes head morphology / MGI
  • abnormal cochlea morphology / MGI
  • abnormal cochlear inner hair cell morphology / MGI
  • increased cochlear nerve compound action potential / MGI
  • abnormal incus morphology / MGI
  • abnormal stapes morphology / MGI
  • impaired hearing / MGI
  • small kidney / MGI
  • absent incus / MGI
  • neonatal lethality, complete penetrance / MGI

Literature references

  • A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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