C3H.C-GarsC201R/H

Status

Available to order

EMMA IDEM:00087
International strain nameC3H.C-GarsC201R/H
Alternative nameGENA201, GENA202
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolGarsC201R,
Gene/Transgene symbolGars

Information from provider

ProviderPat Nolan
Provider affiliationMRC Mammalian Genetics Unit
Genetic informationA T to C transition at base pair 456 results in an amino acid substitution of R for C at residue 201 (C201R).
Phenotypic informationLow limb tone, grip strength and poor wire manoeuvre.
References
  • A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191
  • An ENU-induced mutation in mouse glycyl-tRNA synthetase (GARS) causes peripheral sensory and motor phenotypes creating a model of Charcot-Marie-Tooth type 2D peripheral neuropathy.;Achilli Francesca, Bros-Facer Virginie, Williams Hazel P, Banks Gareth T, AlQatari Mona, Chia Ruth, Tucci Valter, Groves Michael, Nickols Carole D, Seburn Kevin L, Kendall Rachel, Cader Muhammed Z, Talbot Kevin, van Minnen Jan, Burgess Robert W, Brandner Sebastian, Martin Joanne E, Koltzenburg Martin, Greensmith Linda, Nolan Patrick M, Fisher Elizabeth M C, ;2009;Disease models & mechanisms;2;359-73; 19470612

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI allele-associated human disease models

MGI phenotypes (allele matching)
  • hypoactivity / MGI
  • impaired coordination / MGI
  • abnormal sciatic nerve morphology / MGI
  • nervous system phenotype / MGI
  • decreased grip strength / MGI
  • muscle weakness / MGI
  • abnormal sensory neuron morphology / MGI
  • abnormal innervation pattern to muscle / MGI
  • abnormal neuromuscular synapse morphology / MGI
  • decreased body weight / MGI
  • abnormal tibialis anterior morphology / MGI
  • decreased nerve conduction velocity / MGI
  • decreased skeletal muscle fiber number / MGI
  • decreased tibialis anterior weight / MGI
  • impaired limb coordination / MGI
  • abnormal locomotor activation / MGI
  • postnatal lethality, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • abnormal axon morphology / MGI
  • mortality/aging / MGI
  • prenatal lethality / MGI

Literature references

  • A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191
  • An ENU-induced mutation in mouse glycyl-tRNA synthetase (GARS) causes peripheral sensory and motor phenotypes creating a model of Charcot-Marie-Tooth type 2D peripheral neuropathy.;Achilli Francesca, Bros-Facer Virginie, Williams Hazel P, Banks Gareth T, AlQatari Mona, Chia Ruth, Tucci Valter, Groves Michael, Nickols Carole D, Seburn Kevin L, Kendall Rachel, Cader Muhammed Z, Talbot Kevin, van Minnen Jan, Burgess Robert W, Brandner Sebastian, Martin Joanne E, Koltzenburg Martin, Greensmith Linda, Nolan Patrick M, Fisher Elizabeth M C, ;2009;Disease models & mechanisms;2;359-73; 19470612

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Genotyping protocol

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