- hypoactivity / MGI
- impaired coordination / MGI
- abnormal sciatic nerve morphology / MGI
- nervous system phenotype / MGI
- decreased grip strength / MGI
- muscle weakness / MGI
- abnormal sensory neuron morphology / MGI
- abnormal innervation pattern to muscle / MGI
- abnormal neuromuscular synapse morphology / MGI
- decreased body weight / MGI
- abnormal tibialis anterior morphology / MGI
- decreased nerve conduction velocity / MGI
- decreased skeletal muscle fiber number / MGI
- decreased tibialis anterior weight / MGI
- impaired limb coordination / MGI
- abnormal locomotor activation / MGI
- postnatal lethality, complete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- abnormal axon morphology / MGI
- mortality/aging / MGI
- prenatal lethality / MGI
C3H.C-GarsC201R/H
Status | Available to order |
EMMA ID | EM:00087 |
International strain name | C3H.C-GarsC201R/H |
Alternative name | GENA201, GENA202 |
Strain type | Induced Mutant Strains : Chemically-induced |
Allele/Transgene symbol | GarsC201R, |
Gene/Transgene symbol | Gars |
Information from provider
Provider | Pat Nolan |
Provider affiliation | MRC Mammalian Genetics Unit |
Genetic information | A T to C transition at base pair 456 results in an amino acid substitution of R for C at residue 201 (C201R). |
Phenotypic information | Low limb tone, grip strength and poor wire manoeuvre. |
References |
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Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI allele-associated human disease models
MGI phenotypes (allele matching)
Literature references
- A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191
- An ENU-induced mutation in mouse glycyl-tRNA synthetase (GARS) causes peripheral sensory and motor phenotypes creating a model of Charcot-Marie-Tooth type 2D peripheral neuropathy.;Achilli Francesca, Bros-Facer Virginie, Williams Hazel P, Banks Gareth T, AlQatari Mona, Chia Ruth, Tucci Valter, Groves Michael, Nickols Carole D, Seburn Kevin L, Kendall Rachel, Cader Muhammed Z, Talbot Kevin, van Minnen Jan, Burgess Robert W, Brandner Sebastian, Martin Joanne E, Koltzenburg Martin, Greensmith Linda, Nolan Patrick M, Fisher Elizabeth M C, ;2009;Disease models & mechanisms;2;359-73; 19470612
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