- decreased hematocrit / IMPC
- decreased body weight / IMPC
- abnormal startle reflex / IMPC
- increased startle reflex / IMPC
- limb grasping / IMPC
- decreased hemoglobin content / IMPC
- decreased erythrocyte cell number / IMPC
- abnormal locomotor activation / IMPC
- increased lean body mass / IMPC
- decreased circulating iron level / IMPC
- increased blood urea nitrogen level / IMPC
- increased circulating amylase level / IMPC
- decreased prepulse inhibition / IMPC
- increased total body fat amount / IMPC
C3H.C-MecomJbo/H
Status | Available to order |
EMMA ID | EM:00091 |
International strain name | C3H.C-MecomJbo/H |
Alternative name | GENA251 |
Strain type | Induced Mutant Strains : Chemically-induced |
Allele/Transgene symbol | MecomJbo, |
Gene/Transgene symbol | Mecom |
Information from provider
Provider | Nick Parkinson |
Provider affiliation | MRC Mammalian Genetics Unit |
Phenotypic information | These mice have late onset deafness, an extra digit, reduced body weight and craniofacial defects |
References |
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Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Radio-ulnar synostosis-amegakaryocytic thrombocytopenia syndrome / Orphanet_71289
IMPC phenotypes (allele matching)
MGI phenotypes (allele matching)
- abnormal craniofacial morphology / MGI
- polydactyly / MGI
- decreased body weight / MGI
- increased susceptibility to otitis media / MGI
- deafness / MGI
- respiratory system inflammation / MGI
- abnormal neutrophil differentiation / MGI
- abnormal miscarriage rate / MGI
- immune system phenotype / MGI
- abnormal tympanic membrane morphology / MGI
- tympanic membrane perforation / MGI
- abnormal pinna reflex / MGI
- hearing/vestibular/ear phenotype / MGI
- impaired hearing / MGI
- middle ear polyps / MGI
- middle ear effusion / MGI
- distended pericardium / MGI
- abnormal forebrain morphology / MGI
- brachydactyly / MGI
- abnormal limb development / MGI
- perinatal lethality, incomplete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- perinatal lethality, complete penetrance / MGI
Literature references
- A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191
- Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media.;Parkinson Nicholas, Hardisty-Hughes Rachel E, Tateossian Hilda, Tsai Hsun-Tien, Brooker Debra, Morse Sue, Lalane Zuzanna, MacKenzie Francesca, Fray Martin, Glenister Pete, Woodward Anne-Marie, Polley Sian, Barbaric Ivana, Dear Neil, Hough Tertius A, Hunter A Jackie, Cheeseman Michael T, Brown Steve D M, ;2006;PLoS genetics;2;e149; 17029558
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