B6D2-Tg(KRT5-IKBKB)1Armz/Cnbc
Status | Available to order |
EMMA ID | EM:09179 |
International strain name | B6D2-Tg(KRT5-IKBKB)1Armz/Cnbc |
Alternative name | B6D2-Tg(krt5-hIKK2)1Armz |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(KRT5-IKBKB)1Armz, |
Gene/Transgene symbol | Tg(KRT5-IKBKB)1Armz |
Information from provider
Provider | Angel Ramirez |
Provider affiliation | Molecular Oncology Unit, Ciemat |
Additional owner | Dr. A. Page. Molecular Oncology Unit. CIEMAT. Spain |
Genetic information | Transgenic line expressing human IKK2 protein under the regulatory control of elements derived from the bovine Krt5 gene. |
Phenotypic information | Homozygous:UnknownHeterozygous:Hemizygous mice have inflammation of oral epithelia (palate and forestomach). Some of the animals (10% - 20%) show squamous cell carcinoma in any of these epithelia that do not progress with age. |
Breeding history | The line has been maintained by crossing the original founder (B6D2F2 background) to B6D2F1 hybrids, for more than 10 generations. |
References | None available |
Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Disease and phenotype information
MGI allele-associated human disease models
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