STOCK Tg(Camk2a-Grin2c/itTA)12Rsp Tg(tetO-cre)LC1Bjd/Kctt
| Status | Available to order |
| EMMA ID | EM:09256 |
| International strain name | STOCK Tg(Camk2a-Grin2c/itTA)12Rsp Tg(tetO-cre)LC1Bjd/Kctt |
| Alternative name | TgCN12+LC1 (lab name CN12) |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(tetO-cre)LC1Bjd, |
| Gene/Transgene symbol | Tg(tetO-cre)LC1Bjd |
Information from provider
| Provider | Rolf Sprengel |
| Provider affiliation | Molecular Neurobiology, Max Planck Institute for Medicarl Reasearch |
| Genetic information | The transgene CN12 drives the expression of the humanized version of the tTA (itTA) by CamkII promoter and the neuron specific silencer of the grin2C gene specific to excitatory neurons in the forebrain. The transgene LC encodes the tTA dependent luciferase and Cre recombinase under the control of the bidirectional TetO promoter. |
| Phenotypic information | Homozygous:not knownHeterozygous:In the presence of doxycycline in the drinking water the transgenes are not expressed |
| Breeding history | 70 embryos from matings of double transgenic mice with C57BL/6 mice were harvested and cryoconserved in March 2003 |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
| Animals used for archiving | heterozygous 0, wild-type 0 |
| Stage of embryos | 2-cell |
Literature references
- Dissecting spatial knowledge from spatial choice by hippocampal NMDA receptor deletion.;Bannerman David M, Bus Thorsten, Taylor Amy, Sanderson David J, Schwarz Inna, Jensen Vidar, Hvalby Øivind, Rawlins J Nicholas P, Seeburg Peter H, Sprengel Rolf, ;2012;Nature neuroscience;15;1153-9; 22797694
- Stringent doxycycline dependent control of CRE recombinase in vivo.;Schönig Kai, Schwenk Frieder, Rajewsky Klaus, Bujard Hermann, ;2002;Nucleic acids research;30;e134; 12466566