B6;D2-Tg(tetO-lacZ,-GFP/Gria1)A1.1Rsp/Kctt
| Status | Available to order |
| EMMA ID | EM:09257 |
| International strain name | B6;D2-Tg(tetO-lacZ,-GFP/Gria1)A1.1Rsp/Kctt |
| Alternative name | TgTet0GFP-GluA1 (lab name A1.1) |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(tetO-lacZ, -GFP/Gria1)A1.1Rsp |
| Gene/Transgene symbol | Tg(tetO-lacZ,-GFP/Gria1)A1.1Rsp |
Information from provider
| Provider | Rolf Sprengel |
| Provider affiliation | Molecular Neurobiology, Max Planck Institut for Medical Research |
| Genetic information | A transgene for the N-terminal, GFP-tagged AMPA receptor subunit GluA1 (Gria1), together with a nuclear localized lacZ reporter gene, is under the control of the tTA-dependent bidirectional synthetic promoter. |
| Phenotypic information | Homozygous:not knownHeterozygous:The GFP-GluA1 transgene can partially rescue the GluA1 knock-out (Gria1-/-) phenotype |
| Breeding history | Embryos from matings of hemizygote transgenic TgTet0GFP-GluA1 males and (B6D2)F1 females were harvested and 278 embryos were cryoconserved in April 2006 |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
| Animals used for archiving | heterozygous C57BL/6 |
Literature references
- Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient mice.;Mack V, Burnashev N, Kaiser K M, Rozov A, Jensen V, Hvalby O, Seeburg P H, Sakmann B, Sprengel R, ;2001;Science (New York, N.Y.);292;2501-4; 11431570
- Restoration of spatial working memory by genetic rescue of GluR-A-deficient mice.;Schmitt W B, Sprengel R, Mack V, Draft R W, Seeburg P H, Deacon R M J, Rawlins J N P, Bannerman D M, ;2005;Nature neuroscience;8;270-2; 15723058