C57BL/6N-Atm1Brd Chtoptm1a(EUCOMM)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:09273
International strain nameC57BL/6N-Atm1Brd Chtoptm1a(EUCOMM)Wtsi/WtsiH
Alternative nameEPD0635_2_D03
Strain typeTargeted Mutant Strains
Allele/Transgene symbolChtoptm1a(EUCOMM)Wtsi,
Gene/Transgene symbolChtop
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0635_2_D03. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)
  • abnormal joint morphology / IMPC
  • preweaning lethality, complete penetrance / IMPC
MGI phenotypes (allele matching)
  • absent vertebrae / MGI
  • abnormal vertebral body morphology / MGI
  • rib bifurcation / MGI
  • rib fusion / MGI
  • scoliosis / MGI
  • double outlet right ventricle / MGI
  • abnormal maxilla morphology / MGI
  • abnormal rectum morphology / MGI
  • abnormal small intestine placement / MGI
  • abnormal salivary gland morphology / MGI
  • abnormal pineal gland morphology / MGI
  • abnormal thyroid gland morphology / MGI
  • absent spleen / MGI
  • spleen hypoplasia / MGI
  • abnormal forebrain morphology / MGI
  • abnormal choroid plexus morphology / MGI
  • fused dorsal root ganglion / MGI
  • small superior cervical ganglion / MGI
  • small nodose ganglion / MGI
  • internal hemorrhage / MGI
  • abnormal eye morphology / MGI
  • persistent truncus arteriosis / MGI
  • abnormal atrioventricular valve morphology / MGI
  • anal atresia / MGI
  • decreased rib number / MGI
  • absent olfactory bulb / MGI
  • thyroid hypoplasia / MGI
  • urinary bladder hypoplasia / MGI
  • abnormal eye muscle morphology / MGI
  • abnormal Wolffian duct morphology / MGI
  • diaphragmatic hernia / MGI
  • right aortic arch / MGI
  • retroesophageal right subclavian artery / MGI
  • abnormal adenohypophysis morphology / MGI
  • abnormal neurohypophysis morphology / MGI
  • fetal growth retardation / MGI
  • abnormal optic stalk morphology / MGI
  • abnormal optic cup morphology / MGI
  • absent vertebral arch / MGI
  • abnormal cervical atlas morphology / MGI
  • fusion of vertebral arches / MGI
  • decreased cervical vertebrae number / MGI
  • decreased thoracic vertebrae number / MGI
  • holoprosencephaly / MGI
  • abnormal viscerocranium morphology / MGI
  • arteriovenous malformation / MGI
  • abnormal fetal atrioventricular canal morphology / MGI
  • absent dorsal root ganglion / MGI
  • abnormal interventricular foramen morphology / MGI
  • abnormal hyoid bone body morphology / MGI
  • ostium primum atrial septal defect / MGI
  • common atrium / MGI
  • perimembraneous ventricular septal defect / MGI
  • muscular ventricular septal defect / MGI
  • anomalous pulmonary venous connection / MGI
  • bicuspid aortic valve / MGI
  • abnormal hepatic portal vein morphology / MGI
  • fusion of atlas and occipital bones / MGI
  • fused right lung lobes / MGI
  • pelvic kidney / MGI
  • blind ureter / MGI
  • intestinal stenosis / MGI
  • myelocele / MGI
  • absent hypoglossal canal / MGI
  • thin hypoglossal nerve / MGI
  • absent hypoglossal nerve / MGI
  • ductus venosus stenosis / MGI
  • subcutaneous edema / MGI
  • abnormal hepatic portal vein formation / MGI
  • absent celiac artery / MGI
  • abnormal abdominal muscle morphology / MGI
  • abnormal azygos vein topology / MGI
  • abnormal vitelline vein connection / MGI
  • anastomosis between common carotid and vertebral artery / MGI
  • abnormal pancreas topology / MGI
  • abnormal dorsal pancreas topology / MGI
  • abnormal ductus venosus morphology / MGI
  • absent ductus venosus valve / MGI
  • abnormal ductus venosus valve topology / MGI
  • absent costovertebral joint / MGI
  • abnormal brachial plexus formation / MGI
  • abnormal olfactory bulb position / MGI
  • abnormal ureter topology / MGI
  • retro-esophageal left subclavian artery / MGI
  • reduced sympathetic cervical ganglion size / MGI
  • abnormal carotid artery origin / MGI
  • abnormal subclavian artery origin / MGI
  • abnormal vitelline vein topology / MGI
  • absent intrahepatic inferior vena cava segment / MGI
  • absent parasellar internal carotid artery / MGI
  • abnormal vertebral artery topology / MGI
  • absent extracranial vertebral artery segment / MGI
  • embryo cyst / MGI
  • heterochrony / MGI

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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