C57BL/6N-Tg(Ccl19-cre)489Biat/Biat

Status	Available to order
EMMA ID	EM:09381
International strain name	C57BL/6N-Tg(Ccl19-cre)489Biat/Biat
Alternative name	C57BL/6N-Tg(Ccl19-Cre)489Biat
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Ccl19-cre)489Biat,
Gene/Transgene symbol	Tg(Ccl19-cre)489Biat

Information from provider

Provider	Burkhard Ludewig
Provider affiliation	Institut für Immunbiologie, Kantonsspital St. Gallen
Additional owner	Prof. Thomas Rülicke, University of Veterinary Medicine, Vienna, Austria
Genetic information	Transgenic line produced by pronuclear injection of a BAC transgene; random integration with unknown integration site; defined background.
Phenotypic information	Homozygous: Tissue-specific expression of cre-recombinase; no own phenotype. Heterozygous: Tissue-specific expression of cre-recombinase; no own phenotype.
Breeding history	Mating of founder with C57BL/6N.
References	Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity.;Chai Qian, Onder Lucas, Scandella Elke, Gil-Cruz Cristina, Perez-Shibayama Christian, Cupovic Jovana, Danuser Renzo, Sparwasser Tim, Luther Sanjiv A, Thiel Volker, Rülicke Thomas, Stein Jens V, Hehlgans Thomas, Ludewig Burkhard, ;2013;Immunity;38;1013-24; 23623380
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	not known
Immunocompromised	not known

Information from EMMA

Archiving centre	University of Veterinary Medicine, Vienna, Austria
Animals used for archiving	heterozygous C57BL/6N

Literature references

Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity.;Chai Qian, Onder Lucas, Scandella Elke, Gil-Cruz Cristina, Perez-Shibayama Christian, Cupovic Jovana, Danuser Renzo, Sparwasser Tim, Luther Sanjiv A, Thiel Volker, Rülicke Thomas, Stein Jens V, Hehlgans Thomas, Ludewig Burkhard, ;2013;Immunity;38;1013-24; 23623380
IL-17-dependent fibroblastic reticular cell training boosts tissue protective mucosal immunity through IL-10-producing B cells.;Wu Dongwen, Poholek Catherine H, Majumder Saikat, Liu Qixing, Revu Shankar K, Mohib Kanishka, Rothstein David M, McGeachy Mandy J, ;2021;Science immunology;6;eaao3669; 34919443
Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD25.;Kim Dongeon, Kim Mingyo, Kim Tae Woo, Choe Yong-Ho, Noh Hae Sook, Jeon Hyun Min, Kim HyunSeok, Lee Youngeun, Hur Gayeong, Lee Kyung-Mi, Shin Kihyuk, Lee Sang-Il, Lee Seung-Hyo, ;2022;The Journal of experimental medicine;219;; 35315876

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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