C.Cg-Tg(Tcra,Tcrb)562Biat/Biat

Status

Available to order

EMMA IDEM:09382
International strain nameC.Cg-Tg(Tcra,Tcrb)562Biat/Biat
Alternative nameC.CB6-Tg(Tcra,Tcrb)562Biat
Strain typeTransgenic Strains
Allele/Transgene symbolTg(Tcra, Tcrb)562Biat
Gene/Transgene symbolTg(Tcra,Tcrb)562Biat

Information from provider

ProviderBurkhard Ludewig
Provider affiliationInstitut für Immunbiologie, Kantonsspital St. Gallen
Additional ownerProf. Thomas Rülicke, University of Veterinary Medicine, Vienna, Austria
Genetic informationTransgenic line produced by pronuclear injection of a transgene; random integration with unknown integration site; defined background.
Phenotypic informationHomozygous:
Unknown.

Heterozygous:
Spontaneously developing autoimmune myocarditis that progresses to lethal DCM. Cardiac magnetic resonance imaging revealed early inflammation-associated changes in the ventricle wall, including transient thickening of the left ventricle wall. Furthermore, we found that IFN-gamma was a major effector cytokine driving the initial inflammatory process and that the cooperation of IFN-gamma and IL-17A was essential for the development of the progressive disease. This novel TCR transgenic mouse model permits the identification of the central pathophysiological and immunological processes involved in the transition from autoimmune myocarditis to DCM.
Breeding historyMating of founder with BALB/c.
References
  • Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy.;Nindl Veronika, Maier Reinhard, Ratering David, De Giuli Rita, Züst Roland, Thiel Volker, Scandella Elke, Di Padova Franco, Kopf Manfred, Rudin Markus, Rülicke Thomas, Ludewig Burkhard, ;2012;European journal of immunology;42;2311-21; 22730043
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria

Literature references

  • Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy.;Nindl Veronika, Maier Reinhard, Ratering David, De Giuli Rita, Züst Roland, Thiel Volker, Scandella Elke, Di Padova Franco, Kopf Manfred, Rudin Markus, Rülicke Thomas, Ludewig Burkhard, ;2012;European journal of immunology;42;2311-21; 22730043

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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