STOCK Tg(CYP19A1-icre)3Fcrt/Biat
| Status | Available to order |
| EMMA ID | EM:09527 |
| International strain name | STOCK Tg(CYP19A1-icre)3Fcrt/Biat |
| Alternative name | Aromatase-iCre |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(CYP19A1-icre)3Fcrt, |
| Gene/Transgene symbol | Tg(CYP19A1-icre)3Fcrt |
Information from provider
| Provider | Philippe Monget |
| Provider affiliation | INRA |
| Genetic information | The aromatase-iCre transgene was generated by placing the cDNA encoding a mammalian codon-improved Cre recombinase (iCre) followed by an SV40 poly(A) signal under control of the human Cyp19/aromatase(IIa)-278 promoter |
| Phenotypic information | Homozygous:Expression of iCre in Leydig and Sertoli cells.Heterozygous:Expression of iCre in Leydig and Sertoli cells. |
| Breeding history | F1 animals were backcrossed 3 times to obtain individuals that were intercrossed for at least 30 generations |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
| Animals used for archiving | homozygous C57BL/6J, wild-type C57BL/6J |
| Stage of embryos | 2-cell |
Literature references
- Expression of dominant-negative thyroid hormone receptor alpha1 in Leydig and Sertoli cells demonstrates no additional defect compared with expression in Sertoli cells only.;Fumel Betty, Froment Pascal, Holzenberger Martin, Livera Gabriel, Monget Philippe, Fouchécourt Sophie, ;2015;PloS one;10;e0119392; 25793522