MGI phenotypes (allele matching)
B6;129P2-Anxa6tm1Moss/H
| Status | Available to order |
| EMMA ID | EM:09630 |
| International strain name | B6;129P2-Anxa6tm1Moss/H |
| Alternative name | B6;129-Anxa6tm1SM |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Anxa6tm1Moss, |
| Gene/Transgene symbol | Anxa6 |
Information from provider
| Provider | Stephen Moss |
| Provider affiliation | Cell Biology, UCL Institute of Ophthalmology |
| Genetic information | Insertion of neo-pa gene into exon 3 of annexin A6 gene. |
| Phenotypic information | Homozygous:Altered mechanical and intracellular calcium signalling in cardiomyocytes. Displays altered regulation of mitochondrial morphogenesis.Heterozygous:Not studied. |
| Breeding history | Inbred since 1999. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Literature references
- Immunological development and cardiovascular function are normal in annexin VI null mutant mice.;Hawkins T E, Roes J, Rees D, Monkhouse J, Moss S E, ;1999;Molecular and cellular biology;19;8028-32; 10567528
- Altered mechanical properties and intracellular calcium signaling in cardiomyocytes from annexin 6 null-mutant mice.;Song Guojie, Harding Sian E, Duchen Michael R, Tunwell Richard, O'Gara Peter, Hawkins Tim E, Moss Stephen E, ;2002;FASEB journal : official publication of the Federation of American Societies for Experimental Biology;16;622-4; 11919174
- Deficiency of annexins A5 and A6 induces complex changes in the transcriptome of growth plate cartilage but does not inhibit the induction of mineralization.;Belluoccio Daniele, Grskovic Ivan, Niehoff Anja, Schlötzer-Schrehardt Ursula, Rosenbaum Sabrina, Etich Julia, Frie Christian, Pausch Friedericke, Moss Stephen E, Pöschl Ernst, Bateman John F, Brachvogel Bent, ;2010;Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research;25;141-53; 19580468
- Intracellular modulation of signaling pathways by annexin A6 regulates terminal differentiation of chondrocytes.;Minashima Takeshi, Small William, Moss Stephen E, Kirsch Thorsten, ;2012;The Journal of biological chemistry;287;14803-15; 22399299
- Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle-mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response.;Grskovic Ivan, Kutsch Anna, Frie Christian, Groma Gergely, Stermann Jacek, Schlötzer-Schrehardt Ursula, Niehoff Anja, Moss Stephen E, Rosenbaum Sabrina, Pöschl Ernst, Chmielewski Markus, Rappl Gunter, Abken Hinrich, Bateman John F, Cheah Kathryn Se, Paulsson Mats, Brachvogel Bent, ;2012;Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research;27;2399-412; 22692895
- Regulation of mitochondrial morphogenesis by annexin A6.;Chlystun Marcin, Campanella Michelangelo, Law Ah-Lai, Duchen Michael R, Fatimathas Lux, Levine Tim P, Gerke Volker, Moss Stephen E, ;2013;PloS one;8;e53774; 23341998