C3H;C-Alpl^Hpp/H

Status	Available to order
EMMA ID	EM:00097
International strain name	C3H;C-Alpl^Hpp/H
Alternative name	GENA328
Strain type	Induced Mutant Strains : Chemically-induced
Allele/Transgene symbol	Alpl^Hpp,
Gene/Transgene symbol	Alpl

Information from provider

Provider	Tertius Hough
Provider affiliation	MRC Mammalian Genetics Unit
Phenotypic information	Mice with this mutation have low plasma alkaline phosphatase.
References	A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191 Novel mouse model of autosomal semidominant adult hypophosphatasia has a splice site mutation in the tissue nonspecific alkaline phosphatase gene Akp2.;Hough Tertius A, Polewski Monika, Johnson Kristen, Cheeseman Michael, Nolan Patrick M, Vizor Lucie, Rastan Sohaila, Boyde Alan, Pritzker Kenneth, Hunter A Jackie, Fisher Elizabeth M C, Terkeltaub Robert, Brown Steve D M, ;2007;Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research;22;1397-407; 17539739

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI allele-associated human disease models

adult hypophosphatasia / DOID:0110913

Orphanet associated rare diseases, based on orthologous gene matching

Infantile hypophosphatasia / Orphanet_247651
Odontohypophosphatasia / Orphanet_247685
Adult hypophosphatasia / Orphanet_247676
Childhood-onset hypophosphatasia / Orphanet_247667
Perinatal lethal hypophosphatasia / Orphanet_247623
Prenatal benign hypophosphatasia / Orphanet_247638

MGI phenotypes (allele matching)

decreased circulating alkaline phosphatase level / MGI

Literature references

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191
Novel mouse model of autosomal semidominant adult hypophosphatasia has a splice site mutation in the tissue nonspecific alkaline phosphatase gene Akp2.;Hough Tertius A, Polewski Monika, Johnson Kristen, Cheeseman Michael, Nolan Patrick M, Vizor Lucie, Rastan Sohaila, Boyde Alan, Pritzker Kenneth, Hunter A Jackie, Fisher Elizabeth M C, Terkeltaub Robert, Brown Steve D M, ;2007;Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research;22;1397-407; 17539739

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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C3H;C-AlplHpp/H