B6.129P2-Aicdatm1.1(cre/ERT2)Crey/Ph
Status | Available to order |
EMMA ID | EM:09712 |
International strain name | B6.129P2-Aicdatm1.1(cre/ERT2)Crey/Ph |
Alternative name | AICDA-Cre-ERT2 |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Aicdatm1.1(cre/ERT2)Crey, |
Gene/Transgene symbol | Aicda |
Information from provider
Provider | Claude-Agnès Reynaud |
Provider affiliation | INSERM U1151/CNRS UMR 8253, Institut Necker-Enfants Malades |
Genetic information | Knockin of a tamoxifen-inducible form of Cre recombinase at the AICDA locus. |
Phenotypic information | Homozygous:Immunodeficiency due to inactivation of the AICDA gene through targeted Cre-ERT2 insertion.Heterozygous:No obvious phenotype |
Breeding history | 10 backcrosses to C57BL/6 |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | yes |
Information from EMMA
Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Animals used for archiving | heterozygous C57BL/6N |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Hyper-IgM syndrome type 2 / Orphanet_101089
Literature references
- Multiple layers of B cell memory with different effector functions.;Dogan Ismail, Bertocci Barbara, Vilmont Valérie, Delbos Frédéric, Mégret Jérome, Storck Sébastien, Reynaud Claude-Agnès, Weill Jean-Claude, ;2009;Nature immunology;10;1292-9; 19855380
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