MGI phenotypes (allele matching)
B6.129-Calb1tm1Mpin/JBiat
| Status | Available to order |
| EMMA ID | EM:09881 |
| International strain name | B6.129-Calb1tm1Mpin/JBiat |
| Alternative name | B6.129-Calb1tm1Mpin |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Calb1tm1Mpin, |
| Gene/Transgene symbol | Calb1 |
Information from provider
| Provider | Michael Meyer |
| Provider affiliation | Department of Cellular Physiology, LMU München |
| Genetic information | Targeted Mutation (replacement of exon 1 of the Calbindin D28k gene by a targeting vector (PGK-promoter, neo-cassette). |
| Phenotypic information | Homozygous:Mice homozygous for the Calb1 targeted mutation are viable and fertile. They show severe impairment in tests of motor coordination and exhibit ataxia when challenged on a runway. These results suggest functional deficits in cerebellar pathways. Confocal calcium imaging of cerebellar Purkinje cells reveals marked changes of synaptically-evoked postsynaptic calcium transients. No overt phenotype in normal cage environment.Heterozygous:not known (no overt phenotype in normal cage environment) |
| Breeding history | History before 2000 not known; since 2000 backcrossing to C57BL/6J, since 2011 to C57BL/6N. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
| Animals used for archiving | homozygous C57BL/6N |
Disease and phenotype information
Literature references
- Ataxia and altered dendritic calcium signaling in mice carrying a targeted null mutation of the calbindin D28k gene.;Airaksinen M S, Eilers J, Garaschuk O, Thoenen H, Konnerth A, Meyer M, ;1997;Proceedings of the National Academy of Sciences of the United States of America;94;1488-93; 9037080