B6.129P2-Tyk2tm1Biat/Biat
Status | Available to order |
EMMA ID | EM:09882 |
International strain name | B6.129P2-Tyk2tm1Biat/Biat |
Alternative name | B6.129P2-Tyk2 |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Tyk2tm1Biat, |
Gene/Transgene symbol | Tyk2 |
Information from provider
Provider | Mathias Müller |
Provider affiliation | Department for Biomedical Sciences, Institute of Laboratory Animal Science, University of Veterinary Medicine Vienna (Vetmeduni Vienna) |
Additional owner | Prof. Thomas Rülicke, University of Veterinary Medicine, Institute of Laboratory Animal Science, Vienna, Austria |
Genetic information | A neo cassette replaced most of the exons encoding the Jak homology (JH) domains JH7 (partly), JH6/5 and JH4 (partly). Western blot analysis confirmed the absence of protein expression in bone marrow macrophage. (J:65408) |
Phenotypic information | Homozygous:immune deficiencyHeterozygous:not known |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | yes |
Information from EMMA
Archiving centre | University of Veterinary Medicine, Vienna, Austria |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Susceptibility to infection due to TYK2 deficiency / Orphanet_331226
MGI phenotypes (allele matching)
Literature references
- Partial impairment of cytokine responses in Tyk2-deficient mice.;Karaghiosoff M, Neubauer H, Lassnig C, Kovarik P, Schindler H, Pircher H, McCoy B, Bogdan C, Decker T, Brem G, Pfeffer K, Müller M, ;2000;Immunity;13;549-60; 11070173
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