MGI phenotypes (allele matching)
B6;129X1-Tcl1tm1Rso/Cnrm
| Status | Available to order |
| EMMA ID | EM:09917 |
| International strain name | B6;129X1-Tcl1tm1Rso/Cnrm |
| Alternative name | Tcl1_KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Tcl1tm1Rso, |
| Gene/Transgene symbol | Tcl1 |
Information from provider
| Provider | Giandomenico Russo |
| Provider affiliation | oncologia molecolare, IDI-IRCCS |
| Genetic information | In-frame insertion of a PGK-neo cassette replaced sequences that code for exons 2, 3 and 4 of the Tcl1 gene. |
| Phenotypic information | Homozygous:Tcl1-/- mice have a modest impairment in the development and function of the immune system. Maternally derived Tcl1 is essential to early mouse embryo development, thus Tcl1-/- females show fertility defects, while Tcl1-/- males do not. Tcl1-/- adult mice (independently from sex) exhibit hair loss, leading to alopecia with extensive skin lesions.Heterozygous:Both males and females Tcl1+/- mice do not present any discernable defect. |
| Breeding history | The F1 animals were intercrossed for at least 20 generations. |
| References |
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| Homozygous fertile | males only |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- TCL1 participates in early embryonic development and is overexpressed in human seminomas.;Narducci Maria Grazia, Fiorenza Maria Teresa, Kang Sang-Moo, Bevilacqua Arturo, Di Giacomo Monica, Remotti Daniele, Picchio Maria Cristina, Fidanza Vincenzo, Cooper Max D, Croce Carlo Maria, Mangia Franco, Russo Giandomenico, ;2002;Proceedings of the National Academy of Sciences of the United States of America;99;11712-7; 12181493
- Impaired T- and B-cell development in Tcl1-deficient mice.;Kang Sang-Moo, Narducci Maria Grazia, Lazzeri Cristina, Mongiovì Adriana M, Caprini Elisabetta, Bresin Antonella, Martelli Fabio, Rothstein Jay, Croce Carlo Maria, Cooper Max D, Russo Giandomenico, ;2005;Blood;105;1288-94; 15479728
- TCL1 promotes blastomere proliferation through nuclear transfer, but not direct phosphorylation, of AKT/PKB in early mouse embryos.;Fiorenza M T, Torcia S, Canterini S, Bevilacqua A, Narducci M G, Ragone G, Croce C M, Russo G, Mangia F, ;2008;Cell death and differentiation;15;420-2; 17901877
- The Tcl1 oncogene defines secondary hair germ cells differentiation at catagen-telogen transition and affects stem-cell marker CD34 expression.;Ragone G, Bresin A, Piermarini F, Lazzeri C, Picchio M C, Remotti D, Kang S-M, Cooper M D, Croce C M, Narducci M G, Russo G, ;2009;Oncogene;28;1329-38; 19169282