C57BL/6-Atm1Brd Lpar1tm1c(EUCOMM)Wtsi/Flmg
| Status | Available to order |
| EMMA ID | EM:09947 |
| International strain name | C57BL/6-Atm1Brd Lpar1tm1c(EUCOMM)Wtsi/Flmg |
| Alternative name | B6-Lpar1 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Lpar1tm1c(EUCOMM)Wtsi, |
| Gene/Transgene symbol | Lpar1 |
Information from provider
| Provider | Vassilis Aidinis |
| Provider affiliation | Institute of Immunology, B.S.R.C. Al. Fleming |
| Genetic information | This allele was derived from the B6-Lpar1tm1a(EUCOMM)Wtsi/Flmg line (EMMA strain EM:09092), by removing the FRT-flanked LacZ and neomycin selection cassette via flp-mediated recombination. The resulting allele has exon 3 (2nd coding exon; ENSMUSE00001261995) flanked by loxP sites providing conditionality. The absence of the LacZ and neomycin cassette was confirmed by PCR. |
| Phenotypic information | Homozygous:No overt phenotype.Heterozygous:No overt phenotype. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | heterozygous C57BL/6 |
Literature references
- Atx regulates skeletal muscle regeneration via LPAR1 and promotes hypertrophy.;Ray Rashmi, Sinha Sunita, Aidinis Vassilis, Rai Vivek, ;2021;Cell reports;34;108809; 33657371