Helmholtz Zentrum München is the German Research Center for Environmental Health (HMGU). As leading center oriented toward Environmental Health, it focuses on chronic and complex diseases which develop from the interaction of environmental factors and individual genetic disposition. Helmholtz Zentrum München has around 1680 staff members. Helmholtz Zentrum München belongs to the Helmholtz Association, Germany’s largest research organisation, a community of 15 scientific-technical and medical-biological research centers with a total of 26,500 staff members. Prof. Dr. Martin Hrabé de Angelis, the coordinator of Infrafrontier, is head of the Institute of Experimental Genetics (IEG), director of the German Mouse Clinic (GMC) and of the European Mouse Mutant Archive (EMMA).