INFRAFRONTIER is the European Research Infrastructure for Modelling Human Diseases

We contribute to human health by advancing disease prevention and therapies through appropriate models.

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Cryopreservation Protocols EMMA Cre-driver EUCOMM IMPC Rare Disease COVID-19 Cancer

About INFRAFRONTIER

The INFRAFRONTIER consortium consists of more than 20 leading biomedical research institutes in 15 countries working together to understand basic mammalian gene function and model human diseases.

EMMA

The European Mouse Mutant Archive – EMMA is a non-profit repository for the collection, archiving (via cryopreservation) and distribution of relevant mutant mouse and rat strains essential for basic biomedical research.

Resources and Services

In addition to EMMA, INFRAFRONTIER offers other services like axenic derivation, access to open calls and systemic phenotyping.

Animal Welfare and Ethics

Discover INFRAFRONTIER’s commitment to Animal Welfare and explore the ethical research practices we apply to drive the 3R Principle in animal research.

In the Spotlight

NEW

INFRAFRONTIER Conference 2025

28-29 April, Munich: Human Disease Modelling in Rare Diseases. Join over 20 renowned experts in the field and be part of groundbreaking advancements in disease modelling and translational research for rare diseases.

INFRAPLUS

A Horizon-INFRA-DEV project that aims to expand INFRAFRONTIER’s capacity for human disease modelling, refine its service portfolio by reducing animal usage and developing alternative cellular models, and optimise the use of resources.

INFRAFRONTIER Cancer Services

Via the canSERV project, INFRAFRONTIER offers access to several cutting-edge cancer services as Open Calls. These services are offered by INFRAFRONTIER partners with world-leading expertise in cancer research and mouse models.

Axenic Service

This service offers the germ-free derivation of user-provided mouse strains for gnotobiotic studies.

Rodent Disease Model Generation

Generation of custom rodent mutant strains using the latest genome-editing technologies by expert laboratories.

COVID-19 Resources and Services

INFRAFRONTIER offers a cutting-edge COVID-19 therapeutics pipeline, a large selection of COVID-19-related strains and emergency archiving services to aid COVID-19 research and minimise the loss of valuable mouse strains.

IMPC

INFRAFRONTIER is closely linked to the largest and foremost scientific consortium for mouse phenotyping worldwide – the International Mouse Phenotyping Consortium (IMPC).

Strain Distribution

Prices, Delivery Times, Legal Questions and everything you need to know before ordering mutant strains from us.

Strain Collections

Strains originated by large-scale projects archived and distributed by EMMA.

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Press Kit

INFRAFRONTIER Consortium

Upcoming Trainings & Events

EventOn-site

INFRAFRONTIER Conference 2025: Human Disease Modelling in Rare Diseases

28 - 29 April 2025

INFRAFRONTIER

Munich Marriott Hotel City West

EventOnline

TT2025

24 - 27 April 2025

International Society for Transgenic Technologies (ISTT)

Zürich, Switzerland

Lydia Teboul (MLC Harwell)

EventOn-site

FELASA 2025

02 - 05 June 2025

FELASA

Athens, Greece

Asrar Ali Khan, Auke Boersma, Tania Sorg & Maik Dahlhoff

Latest News

Scientific Publication February 17, 2025

ICS Researchers Publish New Advances in CRISPR Genome Editing Efficiency

Our partners at ICS have published a new review exploring how recombinant adeno-associated viruses (rAAV) enhance the efficiency of CRISPR/Cas9 genome editing. The publication highlights recent advances, challenges, and optimisations for generating precise genetic modifications in animal models.

Highlight January 27, 2025

A Mary Lyon Centre GEMM Mouse Model Supports Male Fertility Research

As part of the Mary Lyon Centre’s second GEMM call in 2017, a custom mouse line was generated to support research into the role of a poison exon, the ultra-conserved exon in the splicing regulator gene Tra2b, essential for male fertility.

Scientific Publication January 21, 2025

IMPC impact on preclinical mouse models

A recent article in Mammalian Genome highlights how the International Mouse Phenotyping Consortium accelerates preclinical research and biomedical innovation, providing knockout models and invaluable data to uncover gene functions, identify biomarkers, and advance disease diagnosis, treatment, and prevention.

ALL NEWS