Systemic Phenotyping

The phenotypic analysis of genetically modified mouse models in a systemic, multi-organ approach has become a crucial tool for modern genetics research. INFRAFRONTIER partner institutes are world leaders in systemic phenotyping – and they offer the access to their data, their modern facilities, and their outstanding scientific expertise to all interested research partners in the scientific community.
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INFRAFRONTIER Systemic Phenotyping Service

First described by Gailus-Durner et al. (2009) Gailus-Durner et al. (2009, systemic phenotyping is a broad screening pipeline where mice are analysed systematically covering a wide range of tests to identify novel phenotypes. In other words, it is the systematic analysis of mutant mice through a standardised phenotyping pipeline across a range of biological systems. This type of phenotyping is carried out in mouse clinics within the INFRAFRONTIER consortium and requires large-scale capacity, broad expertise, specific equipment, and dedicated infrastructure.

Systemic phenotyping includes the analysis of:

Energy & Metabolism
Nervous System
Muscles & Bones
Cardiovascular System
Blood Chemistry
Reproductive System
Immune System

The INFRAFRONTIER Systemic Phenotyping service is currently offered by:

German Mouse Clinic (GMC)

Germany’s foremost mouse clinic situated at Helmholtz Munich dedicated to the characterisation of mouse models for human diseases to understand molecular mechanisms of human disorders and for the development of new therapies.

Mary Lyon Center at MRC Harwell

The Mary Lyon Center (MLC) offer a wide range of tests to characterise mouse models of human disease, including investigations of behaviour, metabolism, hearing, and vision. They are constantly striving to develop new tests and extend the range and complexity of established tests to further our understanding of human disease.

This page is still being worked on and will be updated regularly

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