- increased circulating triglyceride level / IMPC
- increased circulating cholesterol level / IMPC
- increased circulating alkaline phosphatase level / IMPC
- increased circulating LDL cholesterol level / IMPC
- decreased circulating glucose level / IMPC
- increased circulating bilirubin level / IMPC
- abnormal tooth morphology / IMPC
- decreased circulating serum albumin level / IMPC
- abnormal glucose homeostasis / IMPC
129.Cg-Tgm2tm1Gml Apoetm1Bres/CljH[cc]
Status | Available to order |
EMMA ID | EM:02064 |
International strain name | 129.Cg-Tgm2tm1Gml Apoetm1Bres/CljH[cc] |
Alternative name | ApoE/tTG |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Apoetm1Bres, Tgm2tm1Gml |
Gene/Transgene symbol | Apoe, Tgm2 |
Information from provider
Provider | Christopher Jackson |
Provider affiliation | University of Bristol |
Genetic information | Targeted null mutation of the apolipoprotein E and tissue transglutaminase genes. |
Phenotypic information | None. |
Breeding history | Outcrossed to 129 for more than 10 generations. Currently bred as a closed outbred colony. |
References |
|
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Sea-blue histiocytosis / Orphanet_158029
- Lipoprotein glomerulopathy / Orphanet_329481
IMPC phenotypes (gene matching)
MGI phenotypes (allele matching)
- abnormal digestive system physiology / MGI
- increased circulating cholesterol level / MGI
- abnormal circulating cholesterol level / MGI
- xanthoma / MGI
- atherosclerotic lesions / MGI
- abnormal circulating LDL cholesterol level / MGI
- abnormal cerebral cortex morphology / MGI
- abnormal hippocampus morphology / MGI
- abnormal neuron morphology / MGI
- increased circulating VLDL cholesterol level / MGI
- increased triglyceride level / MGI
- increased susceptibility to atherosclerosis / MGI
- decreased circulating HDL cholesterol level / MGI
- increased circulating triglyceride level / MGI
- altered response to myocardial infarction / MGI
- abnormal cardiovascular system physiology / MGI
- premature death / MGI
- disorganized myocardium / MGI
- increased myocardial infarction size / MGI
- increased tumor growth/size / MGI
- renal/urinary system phenotype / MGI
- cardiovascular system phenotype / MGI
- immune system phenotype / MGI
- increased macrophage cell number / MGI
- ventricular fibrillation / MGI
- decreased susceptibility to endotoxin shock / MGI
- decreased sensitivity to induced morbidity/mortality / MGI
- abnormal mitochondrial ATP synthesis coupled electron transport / MGI
- decreased hematocrit / MGI
- hyperglycemia / MGI
- decreased circulating insulin level / MGI
- decreased erythrocyte cell number / MGI
- increased insulin sensitivity / MGI
- impaired glucose tolerance / MGI
- increased physiological sensitivity to xenobiotic / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- abnormal thymus morphology / MGI
- impaired macrophage phagocytosis / MGI
- homeostasis/metabolism phenotype / MGI
MGI phenotypes (gene matching)
- abnormal cochlea morphology / MGI
- organ of Corti degeneration / MGI
- abnormal stria vascularis morphology / MGI
- increased bone mineral density / MGI
- abnormal circulating cholesterol level / MGI
- abnormal circulating LDL cholesterol level / MGI
- increased circulating LDL cholesterol level / MGI
- decreased circulating LDL cholesterol level / MGI
- decreased circulating HDL cholesterol level / MGI
- abnormal triglyceride level / MGI
- decreased hematocrit / MGI
- abnormal blood flow velocity / MGI
- abnormal blood vessel physiology / MGI
- alopecia / MGI
- abnormal liver physiology / MGI
- abnormal adrenal gland morphology / MGI
- abnormal immune system morphology / MGI
- abnormal cerebral cortex morphology / MGI
- abnormal hippocampus morphology / MGI
- skin lesions / MGI
- decreased body length / MGI
- decreased body weight / MGI
- corneal opacity / MGI
- retinal degeneration / MGI
- increased anxiety-related response / MGI
- abnormal nursing / MGI
- abnormal locomotor behavior / MGI
- hyperactivity / MGI
- abnormal response to new environment / MGI
- decreased exploration in new environment / MGI
- abnormal spatial learning / MGI
- increased startle reflex / MGI
- decreased startle reflex / MGI
- abnormal kindling response / MGI
- abnormal skeleton physiology / MGI
- abnormal lipid level / MGI
- hyperlipidemia / MGI
- increased circulating triglyceride level / MGI
- increased circulating HDL cholesterol level / MGI
- cardiac hypertrophy / MGI
- abnormal digestive system physiology / MGI
- abnormal postnatal growth / MGI
- hypersecretion of corticosterone / MGI
- increased circulating corticosterone level / MGI
- abnormal immune system physiology / MGI
- lung inflammation / MGI
- vascular inflammation / MGI
- abnormal lung volume / MGI
- deafness / MGI
- abnormal glucose homeostasis / MGI
- premature death / MGI
- abnormal lipid homeostasis / MGI
- abnormal brain morphology / MGI
- abnormal gland physiology / MGI
- abnormal pulmonary alveolus morphology / MGI
- abnormal dendritic cell physiology / MGI
- abnormal cell-mediated immunity / MGI
- increased immunoglobulin level / MGI
- increased IgM level / MGI
- decreased circulating triglyceride level / MGI
- abnormal sciatic nerve morphology / MGI
- abnormal immune serum protein physiology / MGI
- abnormal thermal nociception / MGI
- decreased vertical activity / MGI
- increased thigmotaxis / MGI
- increased heart weight / MGI
- cochlear ganglion degeneration / MGI
- abnormal neuron morphology / MGI
- no phenotypic analysis / MGI
- altered response to CNS ischemic injury / MGI
- abnormal tectorial membrane morphology / MGI
- impaired muscle relaxation / MGI
- increased cholesterol efflux / MGI
- amyloid beta deposits / MGI
- hypopituitarism / MGI
- increased cardiac output / MGI
- nervous system phenotype / MGI
- oxidative stress / MGI
- xanthoma / MGI
- increased autoantibody level / MGI
- abnormal retinal inner nuclear layer morphology / MGI
- abnormal bone structure / MGI
- abnormal myelin sheath morphology / MGI
- abnormal circulating lipid level / MGI
- abnormal plasma membrane morphology / MGI
- increased circulating VLDL triglyceride level / MGI
- decreased circulating VLDL triglyceride level / MGI
- increased circulating phospholipid level / MGI
- arteriosclerosis / MGI
- increased compact bone thickness / MGI
- abnormal basilar membrane morphology / MGI
- cochlear inner hair cell degeneration / MGI
- cochlear outer hair cell degeneration / MGI
- abnormal spiral modiolar artery morphology / MGI
- spiral modiolar artery stenosis / MGI
- increased anti-double stranded DNA antibody level / MGI
- abnormal synaptic vesicle morphology / MGI
- abnormal phospholipid level / MGI
- increased anti-nuclear antigen antibody level / MGI
- increased susceptibility to systemic lupus erythematosus / MGI
- decreased systemic vascular resistance / MGI
- increased spleen weight / MGI
- abnormal osteoblast physiology / MGI
- increased B cell number / MGI
- abnormal response to infection / MGI
- increased susceptibility to parasitic infection / MGI
- increased circulating VLDL cholesterol level / MGI
- decreased circulating VLDL cholesterol level / MGI
- abnormal blood-brain barrier function / MGI
- increased circulating cholesterol level / MGI
- decreased circulating cholesterol level / MGI
- abnormal retinal pigment epithelium morphology / MGI
- abnormal Bruch membrane morphology / MGI
- abnormal cholesterol homeostasis / MGI
- impaired glucose tolerance / MGI
- increased triglyceride level / MGI
- abnormal renal glomerulus morphology / MGI
- atherosclerotic lesions / MGI
- increased susceptibility to atherosclerosis / MGI
- altered susceptibility to atherosclerosis / MGI
- decreased susceptibility to atherosclerosis / MGI
- liver/biliary system phenotype / MGI
- homeostasis/metabolism phenotype / MGI
- behavior/neurological phenotype / MGI
- vascular stenosis / MGI
- abnormal circulating protein level / MGI
- increased susceptibility to weight gain / MGI
- retinal pigment epithelium atrophy / MGI
- abnormal eye electrophysiology / MGI
- decreased circulating glucose level / MGI
- abnormal enzyme/coenzyme activity / MGI
- decreased vasodilation / MGI
- decreased susceptibility to type IV hypersensitivity reaction / MGI
- decreased circulating leptin level / MGI
- decreased cerebral infarction size / MGI
- abnormal epididymal fat pad morphology / MGI
- abnormal T cell number / MGI
- abnormal CD4-positive, alpha beta T cell number / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- increased T-helper 2 cell number / MGI
- abnormal dendrite morphology / MGI
- decreased follicular B cell number / MGI
- increased marginal zone B cell number / MGI
- decreased marginal zone B cell number / MGI
- abnormal B cell activation / MGI
- abnormal adrenal cortex morphology / MGI
- abnormal adrenal medulla morphology / MGI
- abnormal spatial reference memory / MGI
- abnormal spatial working memory / MGI
- thin retinal inner nuclear layer / MGI
- thin retinal outer nuclear layer / MGI
- impaired olfaction / MGI
- increased tumor necrosis factor secretion / MGI
- decreased tumor necrosis factor secretion / MGI
- decreased interferon-gamma secretion / MGI
- increased interleukin-6 secretion / MGI
- decreased interleukin-6 secretion / MGI
- retinal neovascularization / MGI
- abnormal astrocyte physiology / MGI
- abnormal fat cell morphology / MGI
- decreased epididymal fat pad weight / MGI
- abnormal synapse morphology / MGI
- increased prostaglandin level / MGI
- abnormal aorta wall morphology / MGI
- decreased brain cholesterol level / MGI
- kidney microaneurysm / MGI
- increased bone trabecula number / MGI
- increased lung compliance / MGI
- increased airway resistance / MGI
- abnormal lung hysteresivity / MGI
- abnormal kidney arterial blood vessel morphology / MGI
- expanded mesangial matrix / MGI
- mesangiolysis / MGI
- glomerular capillary thrombosis / MGI
- dilated glomerular capillary / MGI
- renal glomerulus lipidosis / MGI
- increased food intake / MGI
- increased fluid intake / MGI
- increased cardiac stroke volume / MGI
- increased or absent threshold for auditory brainstem response / MGI
- decreased circulating homocysteine level / MGI
- decreased brown adipose tissue mass / MGI
- decreased hematocrit / MGI
- altered response to myocardial infarction / MGI
- abnormal thymus morphology / MGI
- increased body weight / MGI
- abnormal cardiovascular system physiology / MGI
- hyperglycemia / MGI
- impaired macrophage phagocytosis / MGI
- premature death / MGI
- disorganized myocardium / MGI
- abnormal T cell physiology / MGI
- decreased circulating insulin level / MGI
- decreased erythrocyte cell number / MGI
- increased insulin sensitivity / MGI
- no phenotypic analysis / MGI
- increased myocardial infarction size / MGI
- abnormal cell adhesion / MGI
- increased tumor growth/size / MGI
- decreased susceptibility to injury / MGI
- impaired glucose tolerance / MGI
- renal/urinary system phenotype / MGI
- homeostasis/metabolism phenotype / MGI
- growth/size/body region phenotype / MGI
- cardiovascular system phenotype / MGI
- immune system phenotype / MGI
- increased macrophage cell number / MGI
- ventricular fibrillation / MGI
- decreased susceptibility to endotoxin shock / MGI
- increased physiological sensitivity to xenobiotic / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- decreased sensitivity to induced morbidity/mortality / MGI
- abnormal mitochondrial ATP synthesis coupled electron transport / MGI
Literature references
- Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.;Plump A S, Smith J D, Hayek T, Aalto-Setälä K, Walsh A, Verstuyft J G, Rubin E M, Breslow J L, ;1992;Cell;71;343-53; 1423598
- Gene disruption of tissue transglutaminase.;De Laurenzi V, Melino G, ;2001;Molecular and cellular biology;21;148-55; 11113189
Information on how we integrate external resources can be found here
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).