B6.129P2-Tg(Dyrk1a)189N3Yah/JmdOrl

Status

Available to order

EMMA IDEM:02119
International strain nameB6.129P2-Tg(Dyrk1a)189N3Yah/JmdOrl
Alternative name189-N3
Strain typeTransgenic Strains
Allele/Transgene symbolTg(Dyrk1a)189N3Yah
Gene/Transgene symbolTg(Dyrk1a)189N3Yah

Information from provider

ProviderJean Maurice Delabar
Provider affiliationEA3508- IFR117- Univ Paris7
Genetic informationElectroporation of a 200kb BAC clone containing the full murine Dyrk1a gene in ES cells (collaboration with Dr Y Herault).
Phenotypic informationBrain defect: volume increase particularly of the ventral part of the brain.
Breeding historyBackcrossed to C57BL/6, N=5
References
  • Transgenic mouse in vivo library of human Down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration.;Branchi Igor, Bichler Zoë, Minghetti Luisa, Delabar Jean Maurice, Malchiodi-Albedi Fiorella, Gonzalez Marie-Claude, Chettouh Zoubidda, Nicolini Alessia, Chabert Caroline, Smith Desmond J, Rubin Edward M, Migliore-Samour Danièle, Alleva Enrico, ;2004;Journal of neuropathology and experimental neurology;63;429-40; 15198122
  • Multi-influential genetic interactions alter behaviour and cognition through six main biological cascades in Down syndrome mouse models.;Duchon Arnaud, Del Mar Muniz Moreno Maria, Martin Lorenzo Sandra, Silva de Souza Marcia Priscilla, Chevalier Claire, Nalesso Valérie, Meziane Hamid, Loureiro de Sousa Paulo, Noblet Vincent, Armspach Jean-Paul, Brault Veronique, Herault Yann, ;2021;Human molecular genetics;30;771-788; 33693642

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI allele-associated human disease models

Literature references

  • Transgenic mouse in vivo library of human Down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration.;Branchi Igor, Bichler Zoë, Minghetti Luisa, Delabar Jean Maurice, Malchiodi-Albedi Fiorella, Gonzalez Marie-Claude, Chettouh Zoubidda, Nicolini Alessia, Chabert Caroline, Smith Desmond J, Rubin Edward M, Migliore-Samour Danièle, Alleva Enrico, ;2004;Journal of neuropathology and experimental neurology;63;429-40; 15198122
  • Multi-influential genetic interactions alter behaviour and cognition through six main biological cascades in Down syndrome mouse models.;Duchon Arnaud, Del Mar Muniz Moreno Maria, Martin Lorenzo Sandra, Silva de Souza Marcia Priscilla, Chevalier Claire, Nalesso Valérie, Meziane Hamid, Loureiro de Sousa Paulo, Noblet Vincent, Armspach Jean-Paul, Brault Veronique, Herault Yann, ;2021;Human molecular genetics;30;771-788; 33693642

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Practical information

Genotyping protocol

Example health report
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Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

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Legally binding conditions for the transfer

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