- abnormal T cell physiology / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- immune system phenotype / MGI
- increased activated T cell number / MGI
- rectal prolapse / MGI
- abnormal colon morphology / MGI
- abnormal intestinal mucosa morphology / MGI
- enlarged spleen / MGI
- spleen hyperplasia / MGI
- colitis / MGI
- increased T cell number / MGI
- diarrhea / MGI
- decreased T cell proliferation / MGI
- increased gamma-delta T cell number / MGI
- enlarged mesenteric lymph nodes / MGI
- abnormal neuron proliferation / MGI
- abnormal thymus cortex morphology / MGI
- increased immunoglobulin level / MGI
- increased IgE level / MGI
- abnormal immune system organ morphology / MGI
- increased autoantibody level / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-nuclear antigen antibody level / MGI
- increased B cell number / MGI
- abnormal T cell morphology / MGI
- small Peyer's patches / MGI
- increased IgG1 level / MGI
- abnormal splenic cell ratio / MGI
- absent thymus medulla / MGI
- enlarged thymus cortex / MGI
- abnormal kidney morphology / MGI
- increased urine protein level / MGI
NOD.Cg-Tcratm1Mjo Tg(TcraCDC35)1Alhn/Orl
Status | Available to order |
EMMA ID | EM:00215 |
International strain name | NOD.Cg-Tcratm1Mjo Tg(TcraCDC35)1Alhn/Orl |
Alternative name | A8 Ca-/- NOD |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Tcratm1Mjo, Tg(TcraCDC35)1Alhn |
Gene/Transgene symbol | Tcra, Tg(TcraCDC35)1Alhn |
Information from provider
Provider | Agnes LEHUEN |
Provider affiliation | U561, Hopital Saint-Vincent-de-Paul, Paris |
Genetic information | Alpha chain of T-cell receptor Va8-Ja37; endogenous alpha chains are knocked out. |
Phenotypic information | Expression of only one TCR alpha chain. |
References |
|
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- abnormal large intestine morphology / MGI
- crypts of Lieberkuhn abscesses / MGI
- rectal prolapse / MGI
- abnormal colon morphology / MGI
- abnormal intestinal mucosa morphology / MGI
- intestinal ulcer / MGI
- abnormal liver morphology / MGI
- enlarged spleen / MGI
- spleen hyperplasia / MGI
- decreased thymocyte number / MGI
- chronic diarrhea / MGI
- decreased IgG level / MGI
- thymus hypoplasia / MGI
- arrested T cell differentiation / MGI
- increased activated T cell number / MGI
- premature death / MGI
- abnormal respiratory system morphology / MGI
- abnormal kidney morphology / MGI
- abnormal T cell differentiation / MGI
- abnormal thymus cortex morphology / MGI
- abnormal double-negative T cell morphology / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal T cell physiology / MGI
- increased immunoglobulin level / MGI
- increased IgE level / MGI
- abnormal immune system organ morphology / MGI
- colitis / MGI
- increased urine protein level / MGI
- abnormal cytokine secretion / MGI
- no phenotypic analysis / MGI
- abnormal intestinal goblet cell morphology / MGI
- increased autoantibody level / MGI
- abnormal T cell subpopulation ratio / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-nuclear antigen antibody level / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- increased B cell number / MGI
- increased T cell number / MGI
- abnormal response to infection / MGI
- diarrhea / MGI
- decreased double-positive T cell number / MGI
- decreased T cell proliferation / MGI
- immune system phenotype / MGI
- abnormal response to transplant / MGI
- abnormal NK T cell morphology / MGI
- abnormal T cell morphology / MGI
- increased NK T cell number / MGI
- absent T cells / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- small Peyer's patches / MGI
- increased gamma-delta T cell number / MGI
- increased gamma-delta intraepithelial T cell number / MGI
- increased mature gamma-delta T cell number / MGI
- enlarged mesenteric lymph nodes / MGI
- decreased IgG2a level / MGI
- increased IgG1 level / MGI
- increased interferon-gamma secretion / MGI
- increased interleukin-10 secretion / MGI
- increased interleukin-2 secretion / MGI
- increased interleukin-4 secretion / MGI
- abnormal T cell receptor alpha chain V-J recombination / MGI
- abnormal splenic cell ratio / MGI
- decreased splenocyte number / MGI
- abnormal neuron proliferation / MGI
- absent thymus medulla / MGI
- enlarged thymus cortex / MGI
Literature references
- Cutting edge: V alpha 14-J alpha 281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice.;Mars Lennart T, Laloux Véronique, Goude Karine, Desbois Sabine, Saoudi Abdelhadi, Van Kaer Luc, Lassmann Hans, Herbelin André, Lehuen Agnès, Liblau Roland S, ;2002;Journal of immunology (Baltimore, Md. : 1950);168;6007-11; 12055208
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