- decreased bone mineral density / IMPC
- decreased body weight / IMPC
- abnormal retina morphology / IMPC
- hyperactivity / IMPC
- abnormal startle reflex / IMPC
- increased startle reflex / IMPC
- abnormal vocalization / IMPC
- abnormal bone mineralization / IMPC
- thrombocytopenia / IMPC
- abnormal locomotor activation / IMPC
- abnormal defecation / IMPC
- increased lean body mass / IMPC
- decreased lean body mass / IMPC
- abnormal behavior / IMPC
- decreased circulating glucose level / IMPC
- decreased prepulse inhibition / IMPC
- increased total body fat amount / IMPC
- decreased grip strength / IMPC
C3H.Cg-Fbxo11Jf/H
Status | Available to order |
EMMA ID | EM:00375 |
International strain name | C3H.Cg-Fbxo11Jf/H |
Alternative name | Jeff |
Strain type | Induced Mutant Strains : Chemically-induced |
Allele/Transgene symbol | Fbxo11Jf, |
Gene/Transgene symbol | Fbxo11 |
Information from provider
Provider | Rachel Hardisty |
Provider affiliation | MRC Harwell, Didcot, Oxon, OX11 0RD |
Phenotypic information | Mice carrying this mutation are small with a short face and are deaf. |
References |
|
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI allele-associated human disease models
IMPC phenotypes (allele matching)
MGI phenotypes (allele matching)
- short snout / MGI
- decreased body weight / MGI
- decreased body size / MGI
- increased susceptibility to otitis media / MGI
- deafness / MGI
- abnormal cytokine secretion / MGI
- abnormal auditory tube / MGI
- decreased endocochlear potential / MGI
- abnormal middle ear ossicle morphology / MGI
- hearing/vestibular/ear phenotype / MGI
- absent pinna reflex / MGI
- abnormal tympanic cavity morphology / MGI
- middle ear polyps / MGI
- middle ear effusion / MGI
- tympanic membrane retraction / MGI
- excessive cerumen / MGI
- abnormal pinna reflex / MGI
- impaired hearing / MGI
- midline facial cleft / MGI
- cleft palate / MGI
- eyelids open at birth / MGI
- neonatal lethality, complete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- short face / MGI
Literature references
- A hearing and vestibular phenotyping pipeline to identify mouse mutants with hearing impairment.;Hardisty-Hughes Rachel E, Parker Andrew, Brown Steve D M, ;2010;Nature protocols;5;177-90; 20057387
- A mutation in the F-box gene, Fbxo11, causes otitis media in the Jeff mouse.;Hardisty-Hughes Rachel E, Tateossian Hilda, Morse Susan A, Romero M Rosario, Middleton Alice, Tymowska-Lalanne Zuzanna, Hunter A Jackie, Cheeseman Michael, Brown Steve D M, ;2006;Human molecular genetics;15;3273-9; 17035249
Information on how we integrate external resources can be found here
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).