C3HeB/FeJ-Hckm1Mhda/Ieg

Status

Available to order

EMMA IDEM:10202
Citation informationRRID:IMSR_EM:10202 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC3HeB/FeJ-Hckm1Mhda/Ieg
Alternative nameC3HeB/FeJ-HckY129HMhda
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolHckm1Mhda
Gene/Transgene symbolHck

Information from provider

ProviderMartin Hrabe de Angelis
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum München
Genetic informationExon 6, c. 385 T to C, p. Tyr129His
Phenotypic informationHomozygous:
Not phenotyped.

Heterozygous:
Not phenotyped.
Breeding historyOutcrossed candidate gene obtained by next generation sequencing of ENU mutagenesis-derived mutant lines.
ReferencesNone available
Homozygous fertilenot known
Homozygous viableyes
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C3H males

Disease and phenotype information

MGI phenotypes (gene matching)
  • atelectasis / MGI
  • thick pulmonary interalveolar septum / MGI
  • overexpanded pulmonary alveoli / MGI
  • abnormal immune system physiology / MGI
  • impaired macrophage phagocytosis / MGI
  • abnormal inflammatory response / MGI
  • lung inflammation / MGI
  • respiratory distress / MGI
  • emphysema / MGI
  • increased lung adenocarcinoma incidence / MGI
  • abnormal pulmonary alveolus morphology / MGI
  • abnormal macrophage physiology / MGI
  • abnormal neutrophil physiology / MGI
  • pulmonary hyperplasia / MGI
  • increased eosinophil cell number / MGI
  • abnormal enzyme/coenzyme activity / MGI
  • pulmonary fibrosis / MGI
  • abnormal alveolar macrophage morphology / MGI
  • increased circulating tumor necrosis factor level / MGI
  • increased interleukin-5 secretion / MGI
  • abnormal respiratory epithelium morphology / MGI
  • respiratory epithelium hypertrophy / MGI
  • decreased lung elastance / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

The information provided on this page is, to the best of EMMA’s knowledge, based on data supplied by the original provider. End users are responsible for reviewing these details and for validating the strain and its suitability for their experimental use.​
Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).