C3HeB/FeJ-Phox2bm1Mhda/Ieg

Status

Available to order

EMMA IDEM:10207
Citation informationRRID:IMSR_EM:10207 

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International strain nameC3HeB/FeJ-Phox2bm1Mhda/Ieg
Alternative nameC3HeB/FeJ-Phox2bD32AMhda (internal lab code Phox-01)
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolPhox2bm1Mhda
Gene/Transgene symbolPhox2b

Information from provider

ProviderMartin Hrabe de Angelis
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum München
Genetic informationExon 1 c.95 T-to-G, p.Asp32Ala PROVEAN prediction:-4.16 (deleterious).
Phenotypic informationHomozygous:
Not phenotyped.

Heterozygous:
Not phenotyped.
Breeding historyOutcrossed candidate gene obtained by next generation sequencing of ENU mutagenesis-derived mutant lines.
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C3H males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • vasculature congestion / MGI
  • abnormal medulla oblongata morphology / MGI
  • small facial motor nucleus / MGI
  • abnormal motor neuron morphology / MGI
  • abnormal sympathetic ganglion morphology / MGI
  • abnormal parasympathetic ganglion morphology / MGI
  • abnormal enteric nervous system morphology / MGI
  • abnormal enteric ganglia morphology / MGI
  • abnormal cranial nerve morphology / MGI
  • absent trigeminal nerve / MGI
  • abnormal vagus nerve morphology / MGI
  • abnormal cranial ganglia morphology / MGI
  • abnormal geniculate ganglion morphology / MGI
  • abnormal petrosal ganglion morphology / MGI
  • abnormal nodose ganglion morphology / MGI
  • small trigeminal ganglion / MGI
  • abnormal glossopharyngeal ganglion morphology / MGI
  • abnormal vagus ganglion morphology / MGI
  • cyanosis / MGI
  • abnormal lung volume / MGI
  • abnormal respiration / MGI
  • abnormal breathing pattern / MGI
  • respiratory failure / MGI
  • apnea / MGI
  • postnatal lethality / MGI
  • abnormal eye morphology / MGI
  • abnormal cardiovascular system morphology / MGI
  • no abnormal phenotype detected / MGI
  • hypoventilation / MGI
  • abnormal respiratory function / MGI
  • abnormal pulmonary ventilation / MGI
  • mydriasis / MGI
  • abnormal autonomic nervous system morphology / MGI
  • abnormal carotid body morphology / MGI
  • abnormal nervous system morphology / MGI
  • abnormal glial cell morphology / MGI
  • abnormal locus ceruleus morphology / MGI
  • abnormal noradrenaline level / MGI
  • abnormal brain interneuron morphology / MGI
  • abnormal area postrema morphology / MGI
  • absent facial nerve / MGI
  • abnormal neuron physiology / MGI
  • abnormal neuronal precursor proliferation / MGI
  • decreased neuronal precursor cell number / MGI
  • abnormal ciliary ganglion morphology / MGI
  • decreased pulmonary ventilation / MGI
  • impaired pupillary reflex / MGI
  • neonatal lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • embryonic lethality during organogenesis, incomplete penetrance / MGI
  • preweaning lethality, incomplete penetrance / MGI
  • abnormal retrotrapezoid nucleus morphology / MGI
  • impaired neuron differentiation / MGI
  • decreased enteric neural crest cell number / MGI
  • decreased enteric neural crest cell proliferation / MGI
  • abnormal enteric neural crest cell migration / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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