C3HeB/FeJ-Ttnm1Mhda/Ieg

Status

Available to order

EMMA IDEM:10210
Citation informationRRID:IMSR_EM:10210 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC3HeB/FeJ-Ttnm1Mhda/Ieg
Alternative nameC3HeB/FeJ-TtnD5939GMhda (internal lab code Ttn-02)
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolTtnm1Mhda
Gene/Transgene symbolTtn

Information from provider

ProviderMartin Hrabe de Angelis
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum München
Genetic informationExon 46 c.17816 T to C, p.Asp5939Gly PROVEAN prediction:-3.033 (deleterious).
Phenotypic informationHomozygous:
Not phenotyped.

Heterozygous:
Not phenotyped.
Breeding historyOutcrossed candidate gene obtained by next generation sequencing of ENU mutagenesis derived mutant lines.
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C3H males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • kyphosis / MGI
  • abnormal angiogenesis / MGI
  • absent organized vascular network / MGI
  • abnormal heart development / MGI
  • abnormal myocardial fiber morphology / MGI
  • ventricular hypoplasia / MGI
  • trabecula carnea hypoplasia / MGI
  • cellular necrosis / MGI
  • microcephaly / MGI
  • muscle degeneration / MGI
  • dystrophic muscle / MGI
  • abnormal skeletal muscle morphology / MGI
  • decreased body weight / MGI
  • abnormal blood vessel morphology / MGI
  • cardiac hypertrophy / MGI
  • abnormal somite development / MGI
  • decreased embryo size / MGI
  • pericardial edema / MGI
  • hemorrhage / MGI
  • premature death / MGI
  • abnormal muscle physiology / MGI
  • abnormal cardiovascular system morphology / MGI
  • abnormal blood circulation / MGI
  • no abnormal phenotype detected / MGI
  • abnormal myocardial trabeculae morphology / MGI
  • abnormal diaphragm morphology / MGI
  • heart left ventricle hypertrophy / MGI
  • thin myocardium / MGI
  • dilated heart left ventricle / MGI
  • dilated cardiomyopathy / MGI
  • decreased heart weight / MGI
  • impaired skeletal muscle contractility / MGI
  • abnormal cardiovascular development / MGI
  • thick ventricular wall / MGI
  • abnormal cardiac muscle contractility / MGI
  • abnormal soleus morphology / MGI
  • abnormal gastrocnemius morphology / MGI
  • abnormal tibialis anterior morphology / MGI
  • abnormal hypaxial muscle morphology / MGI
  • abnormal response/metabolism to endogenous compounds / MGI
  • increased left ventricle diastolic pressure / MGI
  • increased left ventricle systolic pressure / MGI
  • increased left ventricle weight / MGI
  • abnormal heart left ventricle morphology / MGI
  • abnormal heart left atrium morphology / MGI
  • embryonic growth retardation / MGI
  • decreased diastolic filling velocity / MGI
  • abnormal vitelline vascular remodeling / MGI
  • absent heartbeat / MGI
  • abnormal sarcomere morphology / MGI
  • abnormal M line morphology / MGI
  • abnormal myocardial fiber physiology / MGI
  • myositis / MGI
  • enlarged myocardial fiber / MGI
  • abnormal dorsal aorta morphology / MGI
  • hypoxia / MGI
  • decreased cardiac muscle contractility / MGI
  • abnormal heart ventricle morphology / MGI
  • pericardial effusion / MGI
  • abnormal myocardium layer morphology / MGI
  • muscle phenotype / MGI
  • cardiovascular system phenotype / MGI
  • decreased ventricle muscle contractility / MGI
  • cardiac interstitial fibrosis / MGI
  • abnormal muscle contractility / MGI
  • increased apoptosis / MGI
  • abnormal first pharyngeal arch morphology / MGI
  • increased variability of skeletal muscle fiber size / MGI
  • centrally nucleated skeletal muscle fibers / MGI
  • skeletal muscle fiber atrophy / MGI
  • skeletal muscle fiber necrosis / MGI
  • decreased soleus weight / MGI
  • abnormal quadriceps morphology / MGI
  • increased heart left ventricle size / MGI
  • prenatal lethality, complete penetrance / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • embryonic lethality during organogenesis, incomplete penetrance / MGI
  • abnormal frontonasal mesenchyme morphology / MGI
  • increased heart left atrium weight / MGI
  • impaired exercise endurance / MGI
  • increased embryonic tissue cell apoptosis / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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